Cytotoxic Clerodane Diterpenes from Casearia rupestris
- Vieira-Junior, Gerardo M.
- Dutra, Luiz A.
- Ferreira, Paulo M. P.
- de Moraes, Manoel O.
- Lotufo, Leticia V. Costa
- Pessoa, Claudia do O.
- Torres, Roseli Buzanelli
- Boralle, Nivaldo
- Bolzani, Vanderlan da Silva
- Cavalheiro, Alberto José
DOIAbstract
Four new clerodane diterpenes, casearupestrins A-D (1-4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6), All compounds were evaluated for cytotoxicity against a small panel of human cancer cell lines. Caseartipestrin A (1) exhibited the most potent activity against MDA/MB-435 (human Melanoma) and SF-295 (human glioblastoma) cells, superior to that of the standard drug:doxorubicin.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP
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