Aporphine and bisaporphine alkaloids from Aristolochia lagesiana var. intermedia

Corydines, isocorydines, and analogous aporphine alkaloids were isolated from the leaves of Aristolochia lagesiana var intermedia, together with three bisaporphine salts (lagesianines B-D) Their structures were determined by chemical derivatizations and spectroscopic analyses Lagesianines B and C are the first examples of N-CH(2)-N' and C-2-O-C-1' linked dimeric aporphine alkaloids, respectively, while the monomeric units of lagesianine D. which has a carbon skeleton, are linked through C-7-C-5' via ail ethane-1,2-diol group (C-7-CHOHCHOH-C-5') (C) 2009 Elsevier Ltd. All rights reservedFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq