We propose using neural networks to detect data departures from a given reference model, with no prior bias on the nature of the new physics responsible for the discrepancy. The virtues of neural networks as unbiased function approximants make them particularly suited for this task. An algorithm that implements this idea is constructed, as a straightforward application of the likelihood-ratio hypothesis test. The algorithm compares observations with an auxiliary set of reference-distributed events, possibly obtained with a Monte Carlo event generator. It returns a p value, which measures the compatibility of the reference model with the data. It also identifies the most discrepant phase-space region of the data set., to be selected for furt...