Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of non-Hodgkin lymphomas frequently associated with poor prognosis and for which genetic mechanisms of transformation remain incompletely understood. Using RNA sequencing and targeted sequencing, here we identify a recurrent in-frame deletion (VAV1 Δ778-786) generated by a focal deletion-driven alternative splicing mechanism as well as novel VAV1 gene fusions (VAV1-THAP4, VAV1-MYO1F, and VAV1-S100A7) in PTCL. Mechanistically these genetic lesions result in increased activation of VAV1 catalytic-dependent (MAPK, JNK) and non-catalytic-dependent (nuclear factor of activated T cells, NFAT) VAV1 effector pathways. These results support a driver oncogenic role for VAV1 signaling in th...
Introduction: Peripheral T-cell lymphomas represent a rare, heterogeneous group of nodal and extra-n...
Peripheral T-cell lymphoma (PTCL) is heterogenous group of mature T-cell neoplasms characterized by ...
<div><p>Peripheral T cell lymphoma (PTCL) is a heterogeneous malignancy with poor response to curren...
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of non-Hodgkin lymphomas frequently as...
© 2021 The Authors.Mutations in VAV1, a gene that encodes a multifunctional protein important for ly...
Mutations in the VAV1 guanine nucleotide exchange factor 1 have been recently found in peripheral T ...
Peripheral T-cell lymphomas (PTCLs) comprise a heterogeneous group of mature T-cell neoplasms with a...
Peripheral T-cell lymphoma (PTCL) comprises a heterogeneous group of mature T-cell malignancies. Rec...
Historically, the differential diagnosis between different nodal peripheral T-cell lymphoma (PTCL) s...
Peripheral T-cell lymphoma (PTCL) is a group of complex clinicopathological entities, often associat...
Peripheral T-cell Lymphoma (PTCL) consists of numerous distinct disease entities. With the current d...
Peripheral T cell lymphomas (PTCLs) are a heterogeneous and poorly understood group of non-Hodgkin l...
Peripheral T-cell lymphoma (PTCL) is a group of complex clinicopathological entities associated with...
AbstractIntroductionPeripheral T-cell lymphomas represent a rare, heterogeneous group of nodal and e...
Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin lymphomas with poor progno...
Introduction: Peripheral T-cell lymphomas represent a rare, heterogeneous group of nodal and extra-n...
Peripheral T-cell lymphoma (PTCL) is heterogenous group of mature T-cell neoplasms characterized by ...
<div><p>Peripheral T cell lymphoma (PTCL) is a heterogeneous malignancy with poor response to curren...
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of non-Hodgkin lymphomas frequently as...
© 2021 The Authors.Mutations in VAV1, a gene that encodes a multifunctional protein important for ly...
Mutations in the VAV1 guanine nucleotide exchange factor 1 have been recently found in peripheral T ...
Peripheral T-cell lymphomas (PTCLs) comprise a heterogeneous group of mature T-cell neoplasms with a...
Peripheral T-cell lymphoma (PTCL) comprises a heterogeneous group of mature T-cell malignancies. Rec...
Historically, the differential diagnosis between different nodal peripheral T-cell lymphoma (PTCL) s...
Peripheral T-cell lymphoma (PTCL) is a group of complex clinicopathological entities, often associat...
Peripheral T-cell Lymphoma (PTCL) consists of numerous distinct disease entities. With the current d...
Peripheral T cell lymphomas (PTCLs) are a heterogeneous and poorly understood group of non-Hodgkin l...
Peripheral T-cell lymphoma (PTCL) is a group of complex clinicopathological entities associated with...
AbstractIntroductionPeripheral T-cell lymphomas represent a rare, heterogeneous group of nodal and e...
Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin lymphomas with poor progno...
Introduction: Peripheral T-cell lymphomas represent a rare, heterogeneous group of nodal and extra-n...
Peripheral T-cell lymphoma (PTCL) is heterogenous group of mature T-cell neoplasms characterized by ...
<div><p>Peripheral T cell lymphoma (PTCL) is a heterogeneous malignancy with poor response to curren...