Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1000 Genomes Project data, we assessed associations of 11 million genetic variants with EOC risk from 15,437 cases unselected for family history and 30,845 controls and from 15,252 BRCA1 mutation carriers and 8,211 BRCA2 mutation carriers (3,096 with ovarian cancer), and we combined the results in a meta-analysis. This new study design yielded increased statistical power, leading to the discovery of six new EOC susceptibility loci. Variants at 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34....
To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), ...
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To iden...
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To iden...
Genome wide association studies (GWAS) and large scale replication studies have identified common va...
Consortium of Investigators of Modifiers of BRCA1 and BRCA2.-- et al.PMCID: PMC4445140Genome-wide as...
We analyzed 3,872 common genetic variants across the ESR1 locus (encoding estrogen receptor α) in 11...
Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified...
Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regi...
To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), ...
The breast cancer risk variants identified in genome-wide association studies explain only a small f...
Germline mutations in BRCA1 and BRCA2 are associated with increased risks of breast and ovarian canc...
Genome-wide association studies have identified 20 genomic regions associated with risk of epithelia...
To access publisher's full text version of this article click on the hyperlink belowLarge-scale geno...
Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibi...
Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility...
To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), ...
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To iden...
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To iden...
Genome wide association studies (GWAS) and large scale replication studies have identified common va...
Consortium of Investigators of Modifiers of BRCA1 and BRCA2.-- et al.PMCID: PMC4445140Genome-wide as...
We analyzed 3,872 common genetic variants across the ESR1 locus (encoding estrogen receptor α) in 11...
Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified...
Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regi...
To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), ...
The breast cancer risk variants identified in genome-wide association studies explain only a small f...
Germline mutations in BRCA1 and BRCA2 are associated with increased risks of breast and ovarian canc...
Genome-wide association studies have identified 20 genomic regions associated with risk of epithelia...
To access publisher's full text version of this article click on the hyperlink belowLarge-scale geno...
Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibi...
Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility...
To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), ...
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To iden...
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To iden...