Genome-wide association study of colorectal cancer identifies six new susceptibility loci
- Fredrick R. Schumacher
- Schmit, Stephanie L.
- Jiao, Shuo
- Edlund, Christopher K.
- Wang, Hansong
- Zhang, Ben
- Hsu, Li
- Huang, Shu-Chen
- Fischer, Christopher P.
- Harju, John F.
- Idos, Gregory E.
- Lejbkowicz, Flavio
- Manion, Frank J.
- McDonnell, Kevin
- McNeil, Caroline E.
- Melas, Marilena
- Rennert, Hedy S.
- Shi, Wei
- Thomas, Duncan C.
- Berg, David J. Van den
- Hutter, Carolyn M.
- Aragaki, Aaron K.
- Butterbach, Katja
- Caan, Bette J.
- Carlson, Christopher S.
- Chanock, Stephen J.
- Curtis, Keith R.
- Fuchs, Charles S.
- Gala, Manish
- Giovannucci, Edward L.
- Gogarten, Stephanie M.
- Hayes, Richard B.
- Henderson, Brian E.
- Hunter, David J.
- Jackson, Rebecca D. J.
- Kolonel, Laurence N.
- Kooperberg, Charles
- Küry, Sébastien
- LaCroix, Andrea
- Moreno Aguado, Víctor
DOIAbstract
El document inclou una pàgina final amb una correcció (corrigendum). Aquesta, per si sola, té el següent DOI: 10.1038/ncomms9739 i es va publicar al mateix vol. 6.Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and ...
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