Diagnostic protocol for pancreatic neuroendocrine tumors (PNETs)

The advent of endoscopic ultrasonography (EUS) or echoendoscopy (EE) represented a breaking point in the localization and diagnosis of PNETs (1-4) (insulinomas, gastrinomas, glucagonomas, non-functioning, etc.) as it provided a high yield (sensitivity around 90%, specificity at 98%) (5- 10) only second to EUS-FNA (almost 100%) (10-15). New EUS-related technologies such as contrast media and elastography have also improved PNET localization (16-22) with percentages matching those obtained with EUS-FNA