The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9

Tumor-Associated Tn-MUC1 Glycoform Is Internalized through the Macrophage Galactose-Type C-Type Lectin and Delivered to the HLA Class I and II Compartments in Dendritic Cells

Napoletano, C
Rughetti, A
Agervig Tarp, M P
Coleman, J
Picco, G
Sale, P
Denda-Nagai, K
Irimura, T
Mandel, U
Clausen, H
Frati, L
Taylor-Papadimitriou, J
Burchell, J
Nuti, M

September 2007

The type of interaction between tumor-associated antigens and specialized antigen-presenting cells s...

The MUC1 oncomucin regulates pancreatic cancer cell biological properties and chemoresistance. Implication of p42-44 MAPK, Akt, Bcl-2 and MMP13 pathways

Tréhoux, Solange
Duchêne, Bélinda
Jonckheere, Nicolas
van Seuningen, Isabelle

December 2014

International audienceMUC1 is an oncogenic mucin overexpressed in several epithelial cancers, includ...

The Membrane-Bound Mucins: How Large O-Glycoproteins Play Key Roles in Epithelial Cancers and Hold Promise as Biological Tools for Gene-Based and Immunotherapies

Jonckheere, Nicolas
Seuningen, Isabelle, Van

January 2008

International audienceMembrane-bound mucins belong to an ever-increasing family of O-glycopro-teins ...

The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9

Beatson, Richard
Tajadura-Ortega, Virginia
Achkova, Daniela
Picco, Gianfranco
Tsourouktsoglou, Theodora-Dorita
Klausing, Sandra
Hillier, Matthew
Maher, John
Noll, Thomas
Crocker, Paul R.
Taylor-Papadimitriou, Joyce
Burchell, Joy M.

November 2016

Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant glycosyl...

MUC1 and cancer

Taylor-Papadimitriou, J
Burchell, J
Miles, D.W
Dalziel, M

October 1999

AbstractThe MUC1 membrane mucin was first identified as the molecule recognised by mouse monoclonal ...

Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype

Beatson, Richard
Graham, Rosalind
Grundland Freile, Fabio
Cozzetto, Domenico
Kannambath, Shichina
Pfeifer, Ester
Woodman, Natalie
Owen, Julie
Nuamah, Rosamond
Mandel, Ulla
Pinder, Sarah
Gillett, Cheryl
Noll, Thomas
Bouybayoune, Ihssane
Taylor-Papadimitriou, Joyce
Burchell, Joy M

January 2020

Beatson R, Graham R, Grundland Freile F, et al. Cancer-associated hypersialylated MUC1 drives the di...

Recombinant tumor associated MUC1 impairs differentiation and function of Dendritic Cells

Rughetti, A.
Pellicciotta, I.
Nuti, M.
Biffoni, M.
Bäckström, M.
Link, T.
Noll, T.
Hansson, G. C.
Clausen, H.
Burchell, J. M.
Taylor-Papadimitriou, J.

January 2005

Tumors exploit several strategies to evade immune recognition, including the production of a large n...

Natural and Induced Humoral Responses to MUC1

Silvia Von Mensdorff-Pouilly
Maria Moreno
René H. M. Verheijen

July 2011

MUC1 is a membrane-tethered mucin expressed on the ductal cell surface of glandular epithelial cells...

Impact of MUC1 Mucin Downregulation in the Phenotypic Characteristics of MKN45 Gastric Carcinoma Cell Line

Costa Natália R.
Paulo Paula
Caffrey Thomas
Hollingsworth Michael A.
Santos-Silva Filipe

November 2011

Gastric carcinoma is the second leading cause of cancer-associated death worldwide. The high mortali...

The mucin MUC1 modulates the tumor immune microenvironment through the engagement of Siglec-9

Beatson, Richard
Tajadura-Ortega, Virginia
Achkova, Daniela Yordanova
Picco, Gianfranco
Tsourouktsoglou, Theodora-Dorita
Klausing, Sandra
Hillier, Matthew
Maher, John
Noll, Thomas
Crocker, Paul
Taylor-Papadimitriou, Joyce
Burchell, Joy

November 2016

Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant glycosyl...

Muc1/sec: A Secreted Alternative Splice Variant Of Muc1 That Promotes Tumor Immunity

Grosso, Joseph Frank

January 2004

Human MUC1/sec is a secreted form of the glycoprotein mucin 1 (MUC1). In order to characterize the r...

MUC1 Expression Affects the Immunoflogosis in Renal Cell Carcinoma Microenvironment through Complement System Activation and Immune Infiltrate Modulation

Lucarelli, Giuseppe
Netti, Giuseppe Stefano
Rutigliano, Monica
Lasorsa, Francesco
Loizzo, Davide
Milella, Martina
Schirinzi, Annalisa
Fontana, Antonietta
Di Serio, Francesca
Tamma, Roberto
Ribatti, Domenico
Battaglia, Michele
Ranieri, Elena
Ditonno, Pasquale

January 2023

Mucin1 (MUC1), a glycoprotein associated with an aggressive cancer phenotype and chemoresistance, is...

Recombinant tumor-associated MUC1 glycoprotein impairs the differentiation and function of dendritic cells.

RUGHETTI A
PELLICCIOTTA I
BIFFONI M
BACKSTROM M
LINK T
BENNET EP
CLAUSEN H
NOLL T
HANSSON GC
BURCHELL JM
FRATI L
TAYLOR-PAPADIMITRIOU J
M. NUTI

January 2005

Tumors exploit several strategies to evade immune recognition, including the production of a large n...

MUC1: Structure, Function, and Clinic Application in Epithelial Cancers

Wenqing Chen
Zhu Zhang
Shiqing Zhang
Peili Zhu
Joshua Ka-Shun Ko
Ken Kin-Lam Yung

June 2021

The transmembrane glycoprotein mucin 1 (MUC1) is a mucin family member that has different functions ...

Tumor Associated Tn-MUC1 Glycoform is Internalized through the Macrophage Galactose-type C-type Lectin and delivered to the HLA Class I and II Compartments in Dendritic Cells.

NAPOLETANO, Chiara
RUGHETTI, Aurelia
SALE, PATRIZIO
FRATI, Luigi
NUTI, Marianna
AGERVIG TARP MP
COLEMAN J
BENNETT EP
PICCO G
DENDA NAGAI K
IRIMURA T
MANDEL U
CLAUSEN H
TAYLOR PAPADIMITRIOU J
BURCHELL J

January 2007

The type of interaction between tumor-associated antigens and specialized antigen-presenting cells s...

Tumor-Associated Tn-MUC1 Glycoform Is Internalized through the Macrophage Galactose-Type C-Type Lectin and Delivered to the HLA Class I and II Compartments in Dendritic Cells

Napoletano, C
Rughetti, A
Agervig Tarp, M P
Coleman, J
Picco, G
Sale, P
Denda-Nagai, K
Irimura, T
Mandel, U
Clausen, H
Frati, L
Taylor-Papadimitriou, J
Burchell, J
Nuti, M

September 2007

The type of interaction between tumor-associated antigens and specialized antigen-presenting cells s...

The MUC1 oncomucin regulates pancreatic cancer cell biological properties and chemoresistance. Implication of p42-44 MAPK, Akt, Bcl-2 and MMP13 pathways

Tréhoux, Solange
Duchêne, Bélinda
Jonckheere, Nicolas
van Seuningen, Isabelle

December 2014

International audienceMUC1 is an oncogenic mucin overexpressed in several epithelial cancers, includ...

The Membrane-Bound Mucins: How Large O-Glycoproteins Play Key Roles in Epithelial Cancers and Hold Promise as Biological Tools for Gene-Based and Immunotherapies

Jonckheere, Nicolas
Seuningen, Isabelle, Van

January 2008

International audienceMembrane-bound mucins belong to an ever-increasing family of O-glycopro-teins ...

The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9

Beatson, Richard
Tajadura-Ortega, Virginia
Achkova, Daniela
Picco, Gianfranco
Tsourouktsoglou, Theodora-Dorita
Klausing, Sandra
Hillier, Matthew
Maher, John
Noll, Thomas
Crocker, Paul R.
Taylor-Papadimitriou, Joyce
Burchell, Joy M.

November 2016

Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant glycosyl...

MUC1 and cancer

Taylor-Papadimitriou, J
Burchell, J
Miles, D.W
Dalziel, M

October 1999

AbstractThe MUC1 membrane mucin was first identified as the molecule recognised by mouse monoclonal ...

Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype

Beatson, Richard
Graham, Rosalind
Grundland Freile, Fabio
Cozzetto, Domenico
Kannambath, Shichina
Pfeifer, Ester
Woodman, Natalie
Owen, Julie
Nuamah, Rosamond
Mandel, Ulla
Pinder, Sarah
Gillett, Cheryl
Noll, Thomas
Bouybayoune, Ihssane
Taylor-Papadimitriou, Joyce
Burchell, Joy M

January 2020

Beatson R, Graham R, Grundland Freile F, et al. Cancer-associated hypersialylated MUC1 drives the di...

Recombinant tumor associated MUC1 impairs differentiation and function of Dendritic Cells

Rughetti, A.
Pellicciotta, I.
Nuti, M.
Biffoni, M.
Bäckström, M.
Link, T.
Noll, T.
Hansson, G. C.
Clausen, H.
Burchell, J. M.
Taylor-Papadimitriou, J.

January 2005

Tumors exploit several strategies to evade immune recognition, including the production of a large n...

Natural and Induced Humoral Responses to MUC1

Silvia Von Mensdorff-Pouilly
Maria Moreno
René H. M. Verheijen

July 2011

MUC1 is a membrane-tethered mucin expressed on the ductal cell surface of glandular epithelial cells...

Impact of MUC1 Mucin Downregulation in the Phenotypic Characteristics of MKN45 Gastric Carcinoma Cell Line

Costa Natália R.
Paulo Paula
Caffrey Thomas
Hollingsworth Michael A.
Santos-Silva Filipe

November 2011

Gastric carcinoma is the second leading cause of cancer-associated death worldwide. The high mortali...

The mucin MUC1 modulates the tumor immune microenvironment through the engagement of Siglec-9

Beatson, Richard
Tajadura-Ortega, Virginia
Achkova, Daniela Yordanova
Picco, Gianfranco
Tsourouktsoglou, Theodora-Dorita
Klausing, Sandra
Hillier, Matthew
Maher, John
Noll, Thomas
Crocker, Paul
Taylor-Papadimitriou, Joyce
Burchell, Joy

November 2016

Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant glycosyl...

Muc1/sec: A Secreted Alternative Splice Variant Of Muc1 That Promotes Tumor Immunity

Grosso, Joseph Frank

January 2004

Human MUC1/sec is a secreted form of the glycoprotein mucin 1 (MUC1). In order to characterize the r...

MUC1 Expression Affects the Immunoflogosis in Renal Cell Carcinoma Microenvironment through Complement System Activation and Immune Infiltrate Modulation

Lucarelli, Giuseppe
Netti, Giuseppe Stefano
Rutigliano, Monica
Lasorsa, Francesco
Loizzo, Davide
Milella, Martina
Schirinzi, Annalisa
Fontana, Antonietta
Di Serio, Francesca
Tamma, Roberto
Ribatti, Domenico
Battaglia, Michele
Ranieri, Elena
Ditonno, Pasquale

January 2023

Mucin1 (MUC1), a glycoprotein associated with an aggressive cancer phenotype and chemoresistance, is...

Recombinant tumor-associated MUC1 glycoprotein impairs the differentiation and function of dendritic cells.

RUGHETTI A
PELLICCIOTTA I
BIFFONI M
BACKSTROM M
LINK T
BENNET EP
CLAUSEN H
NOLL T
HANSSON GC
BURCHELL JM
FRATI L
TAYLOR-PAPADIMITRIOU J
M. NUTI

January 2005

Tumors exploit several strategies to evade immune recognition, including the production of a large n...

MUC1: Structure, Function, and Clinic Application in Epithelial Cancers

Wenqing Chen
Zhu Zhang
Shiqing Zhang
Peili Zhu
Joshua Ka-Shun Ko
Ken Kin-Lam Yung

June 2021

The transmembrane glycoprotein mucin 1 (MUC1) is a mucin family member that has different functions ...

Tumor Associated Tn-MUC1 Glycoform is Internalized through the Macrophage Galactose-type C-type Lectin and delivered to the HLA Class I and II Compartments in Dendritic Cells.

NAPOLETANO, Chiara
RUGHETTI, Aurelia
SALE, PATRIZIO
FRATI, Luigi
NUTI, Marianna
AGERVIG TARP MP
COLEMAN J
BENNETT EP
PICCO G
DENDA NAGAI K
IRIMURA T
MANDEL U
CLAUSEN H
TAYLOR PAPADIMITRIOU J
BURCHELL J

January 2007

The type of interaction between tumor-associated antigens and specialized antigen-presenting cells s...

Tumor-Associated Tn-MUC1 Glycoform Is Internalized through the Macrophage Galactose-Type C-Type Lectin and Delivered to the HLA Class I and II Compartments in Dendritic Cells

Napoletano, C
Rughetti, A
Agervig Tarp, M P
Coleman, J
Picco, G
Sale, P
Denda-Nagai, K
Irimura, T
Mandel, U
Clausen, H
Frati, L
Taylor-Papadimitriou, J
Burchell, J
Nuti, M

September 2007

The type of interaction between tumor-associated antigens and specialized antigen-presenting cells s...

The MUC1 oncomucin regulates pancreatic cancer cell biological properties and chemoresistance. Implication of p42-44 MAPK, Akt, Bcl-2 and MMP13 pathways

Tréhoux, Solange
Duchêne, Bélinda
Jonckheere, Nicolas
van Seuningen, Isabelle

December 2014

International audienceMUC1 is an oncogenic mucin overexpressed in several epithelial cancers, includ...

The Membrane-Bound Mucins: How Large O-Glycoproteins Play Key Roles in Epithelial Cancers and Hold Promise as Biological Tools for Gene-Based and Immunotherapies

Jonckheere, Nicolas
Seuningen, Isabelle, Van

January 2008

International audienceMembrane-bound mucins belong to an ever-increasing family of O-glycopro-teins ...

The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9

Abstract

Extracted data

The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9

Abstract

Extracted data

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