STAT5B WT Dimer
- de Araujo, Elvin D.
- Erdogan, Fettah
- Neubauer, Heidi A.
- Meneksedag-Erol, Deniz
- Manaswiyoungkul, Pimyupa
- Eram, Mohammad S.
- Seo, Hyuk-Soo
- Qadree, Abdul K.
- Israelian, Johan
- Orlova, Anna
- Suske, Tobias
- Pham, Ha T. T.
- Boersma, Auke
- Tangermann, Simone
- Kenner, Lukas
- Rülicke, Thomas
- Dong, Aiping
- Ravichandran, Manimekalai
- Brown, Peter J.
- Audette, Gerald F.
- Rauscher, Sarah
- Dhe-Paganon, Sirano
- Moriggl, Richard
- Gunning, Patrick T.
Publication date
April 2019
DOIAbstract
The simulation trajectory for the STAT5B dimer (system 3) over 75 ns. The CCD (cyan), DBD (blue), linker domain (purple) and SH2 domain (orange) are all shown with residue N642 highlighted in green. A smoothing window of 5 frames was applied using VMD, and the protein was aligned to the conformation obtained after the equilibration simulations. Water and ions are not shown for clarity. As can be seen in the movie, the inter-monomer contacts are lost at ~75 ns, resulting in dissociation and dimer separation
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