PENGARUH OMEGA 3 POLYUNSATURATED FATTY ACIDS TERHADAP KADAR IL-8 SERUM, NILAI %VEP1, DAN SKOR CAT PADA PENDERITA PPOK STABIL

Cigarette smoke inhalation and the other exposure can cause of airway inflammatory and it was the most cause of COPD pathogenesis. The airway inflammatory will release cytokines proinflammation, one of them was interleukin (IL)-8. Omega 3 polyunsaturated fatty acids (PUFAs) have anti-inflammatory effect and its can decrease cytokines production in COPD pathogenesis. This study aimed to analyze effects of omega 3 PUFAs on serum IL-8, %VEP1, and CAT score in stable COPD patients. Clinical trials of experimental with pretest and posttest designs were conducted of 32 stable COPD patients came to clinic in Dr. Moewardi Hospital Surakarta from December 2016 until February 2017. Samples were taken by consecutive sampling. Subjects were divided into two groups include the treatment group (n=16) received standard COPD therapy+omega 3 PUFAs 600mg / day and the control group (n=16) received only standard COPD therapy for 28 days. There were significant difference (p=0.000) towards decreased of serum IL-8 plasma between treatment group (-3.56+5.32pg/ml) and control group (8.90+9.98pg/ml), increase difference were no significantly of %VEP1 value (p=0.473) between treatment group (7.02+7.17pg/ml) and control group (5.32+5.97pg/ml), decrease difference of CAT scores significantly (p=0.000) between treatment group (-16.13+3.03pg/ml) and control group (-4.75+4.17pg/ml). The addition of Omega 3 PUFAs may decrease airway inflammation with decrease serum IL-8 level significantly, increase of %VEP1no significantly, and improve the clinical symptoms of stable COPD by decrease of CAT scores significantly in stable COPD patients. Keywords: Omega 3 Polyunsaturated fatty acids, COPD stable, IL-8 serum,% VEP1, CAT scores