PENGARUH OMEGA 3 POLYUNSATURATED FATTY ACIDS TERHADAP KADAR IL-8 SERUM, NILAI %VEP1, DAN SKOR CAT PADA PENDERITA PPOK STABIL

ABSTRACT NISFI ANGRIANI, NIM : S501202049. 2017. Effects of omega 3 pulyunsaturated fatty acids to the serum level of IL-8, % VEP1 , and COPD assessment test scores in stable COPD patients. THESIS. Adviser I : Prof.Dr.Suradi,dr.,Sp.P(K),MARS, FISR. Adviser II : Dr. Yusup Subagio Sutanto, dr., Sp.P(K), FISR. Master of Family Medicine, Postgraduate Program, Sebelas Maret University Surakarta. Abstract Introduction: Cigarette smoke inhalation and the other exposure can cause of airway inflammatory and it was the most cause of COPD pathogenesis. The airway inflammatory will release cytokines proinflammation, one of them was interleukin (IL)-8. Omega 3 polyunsaturated fatty acids (PUFAs) have anti-inflammatory effect and its can decrease cytokines production in COPD pathogenesis. Methods: This study aimed to analyze effects of omega 3 PUFAs on serum IL-8, %VEP1, and CAT score in stable COPD patients. Clinical trials of experimental with pretest and posttest designs were conducted of 32 stable COPD patients came to clinic in Dr. Moewardi Hospital Surakarta from December 2016 until February 2017. Samples were taken by consecutive sampling. Subjects were divided into two groups include the treatment group (n=16) received standard COPD therapy+omega 3 PUFAs 600mg / day and the control group (n=16) received only standard COPD therapy for 28 days. Results: There were significant difference (p=0.000) towards decreased of serum IL-8 plasma between treatment group (-3.56+5.32pg/ml) and control group (8.90+9.98pg/ml), increase difference were no significantly of %VEP1 value (p=0.473) between treatment group (7.02+7.17pg/ml) and control group (5.32+5.97pg/ml), decrease difference of CAT scores significantly (p=0.000) between treatment group (-16.13+3.03pg/ml) and control group (-4.75+4.17pg/ml). Conclusions: Omega 3 PUFAs may decrease airway inflammation with decrease serum IL-8 level significantly, increase of %VEP1no significantly, and improve the clinical symptoms of stable COPD by decrease of CAT scores significantly in stable COPD patients. Keywords: Omega 3 Polyunsaturated fatty acids, COPD stable, IL-8 serum,% VEP1, CAT scores. ABSTRAK NISFI ANGRIANI, NIM : S501202049. 2017. Pengaruh omega 3 polyunsaturated fatty acids terhadap kadar IL-8 serum, nilai 5VEP1, dan skor CAT pada penderita PPOK stabil. TESIS. Pembimbing I : Prof.Dr.Suradi,dr.,Sp.P(K),MARS, FISR. Pembimbing II : Dr. Yusup Subagio Sutanto, dr., Sp.P(K), FISR. Program Studi Kedokteran Keluarga, Program Pascasarjana, Universitas Sebelas Maret Surakarta. Pendahuluan:Inhalasi asap rokok dan paparan lainnya dapat menyebabkan inflamasi saluran napas dan merupakan penyebab terbanyak pada patogenesis PPOK. Inflamasi saluran napas akan melepaskan sitokin proinflamasi, salah satunya adalah interleukin (IL)-8. Omega 3 polyunsaturated fatty acids (PUFA) memiliki efek anti inflamasi dan dapat menurunkan produksi sitokin pada patogenesis PPOK. Metode:Penelitian ini bertujuan untuk menganalisis pengaruh omega 3 PUFA terhadap IL-8 serum, %VEP1, dan skor COPD assessment test (CAT) pada penderita PPOK stabil. Uji klinis eksperimental dengan pretest and post-test design pada 32 penderita PPOK stabil yang datang ke poliklinik paru RSUD. Dr.Moewardi Surakarta dari bulan Desember 2016-Februari 2017. Sampel diambil secara consecutive sampling. Subjek dibagi dalam dua kelompok meliputi kelompok perlakuan (n=16) mendapatkan terapi standar PPOK stabil+Omega 3 PUFA 600mg/hari dan kelompok kontrol (n=16) hanya mendapatkan terapi standar PPOK stabil selama 28 hari. Hasil:Terdapat perbedaan signifikan (p=0,000) penurunan kadar IL-8 serum kelompok perlakuan (-3,56+5,32pg/ml) dibanding kontrol (8,90+9,98pg/ml), perbedaan tidak signifikan (p=0,473) peningkatan nilai %VEP1 kelompok perlakuan (7,02+7,17pg/ml) dibanding kontrol (5,32+5,97pg/ml), perbedaan signifikan (p=0,000) penurunan skor CAT kelompok perlakuan (-16,13+3,03pg/ml) dibanding kontrol (-4,75+4,17pg/ml). Simpulan:Penambahan omega 3 PUFA 1x600 mg/hari selama 28 hari dapat menurunkan kadar IL-8 serum signifikan, meningkatkan nilai %VEP1 tidak signifikan, dan menurunkan skor CAT signifikan pada penderita PPOK stabil. Kata kunci: Omega 3 PUFA, PPOK stabil, IL-8 serum, %VEP1, skor COPD assessment test