Boron-doped diamond electrodes with different boron content – Determination of leucovorin.

Elektrochemické vlastnosti borem dopovaných diamantových elektrod s různým obsahem boru byly studovány pomocí cyklické voltametrie redoxních systémů ([Ru(NH3)6]3+/2+) a ([Fe(CN6)]4−/3−). Aplikační možnosti těchto elektrod elektrod byly testovány při stanovení leukovorinu.Electrochemical properties of boron-doped diamond electrodes (BDDEs) with different boron content were studied using cyclic voltammetry of inner-sphere ([Ru(NH3)6]3+/2+) and outer-sphere ([Fe(CN6)]4−/3−) redox markers. Their application possibilities in analysis of organic bioactive compounds were tested by determination of drug leucovorin in model solutions as well as in pharmaceutical preparations. Voltammetric behavior of leucovorin was studied and voltammetric method for its determination was developed using commercially available BDDE. This proposed method was applied for lab-made BDDEs and the appropriated statistical parameters (e.g., LDR, LOD, LOQ, and RSD) were calculated and compared with respect to the boron content