Disruption of leptin signalling has been implicated as playing a role in the development of Alzheimer's disease (AD). Leptin has previously been shown to be affected by amyloid-beta (Aβ)-related signalling; however, pathways that link leptin to the disease pathogenesis have not been determined. To characterize the association between increasing age-dependent Aβ levels with leptin signalling and the vulnerable brain regions in AD, we assessed the mRNA and protein expression profile of leptin and leptin receptor (Ob-Rb) at 9 and 18-month-age in APP/PS1 mice. Immunohistochemical labelling demonstrated that leptin and Ob-Rb proteins were localised to neocortical and hippocampal neurons in APP/PS1 and wildtype (WT) mice. Neuronal leptin and Ob-R...
Accumulation of amyloid-β (Aβ1-42) is a key event mediating the cognitive deficits in Alzheimer’s di...
It is well established that the endocrine hormone leptin plays a pivotal role in regulating food int...
Leptin has been suggested to play a role in amyotrophic lateral sclerosis (ALS), a fatal progressive...
Disruption of leptin signalling has been implicated as playing a role in the development of Alzheime...
A growing body of evidence suggests that β-amyloid peptides (Aβ) are unlikely to be the only factor ...
A growing body of evidence suggests that ?-amyloid peptides (A?) are unlikely to be the only factor ...
Several studies support the relation between leptin and Alzheimer’s disease (AD). We show that lepti...
Several studies support the relation between leptin and Alzheimer’s disease (AD). We show that lepti...
It is widely accepted that the metabolic hormone leptin regulates food intake and body weight via ac...
Accumulation of amyloid-β (Aβ) is a key event mediating the cognitive deficits in Alzheimer's diseas...
Accumulation of amyloid-β (Aβ1-42) is a key event mediating the cognitive deficits in Alzheimer’s di...
It is well established that the endocrine hormone leptin plays a pivotal role in regulating food int...
Leptin has been suggested to play a role in amyotrophic lateral sclerosis (ALS), a fatal progressive...
Disruption of leptin signalling has been implicated as playing a role in the development of Alzheime...
A growing body of evidence suggests that β-amyloid peptides (Aβ) are unlikely to be the only factor ...
A growing body of evidence suggests that ?-amyloid peptides (A?) are unlikely to be the only factor ...
Several studies support the relation between leptin and Alzheimer’s disease (AD). We show that lepti...
Several studies support the relation between leptin and Alzheimer’s disease (AD). We show that lepti...
It is widely accepted that the metabolic hormone leptin regulates food intake and body weight via ac...
Accumulation of amyloid-β (Aβ) is a key event mediating the cognitive deficits in Alzheimer's diseas...
Accumulation of amyloid-β (Aβ1-42) is a key event mediating the cognitive deficits in Alzheimer’s di...
It is well established that the endocrine hormone leptin plays a pivotal role in regulating food int...
Leptin has been suggested to play a role in amyotrophic lateral sclerosis (ALS), a fatal progressive...