A one-pot route to thioamides discovered by gas-phase studies: palladium-mediated CO2 extrusion followed by insertion of isothiocyanates
- Noor, A
- Li, J
- Khairallah, GN
- Li, Z
- Ghari, H
- Canty, AJ
- Ariafard, A
- Donnelly, PS
- O'Hair, RAJ
DOIAbstract
A new palladium mediated “one pot” synthesis of thioamides from aromatic carboxylic acids (ArCO2H + RNCS → ArC(S)NHR + CO2) was discovered by gas-phase experiments and theoretical studies. Palladium-mediated decarboxylation of aromatic carboxylic acids followed by addition of substituted isothiocyanates leads to the corresponding thioamide derivatives
Add to ORKG