y New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
- Lu, Yingchang
- Day, Felix R.
- Gustafsson, Stefan
- Buchkovich, Martin L.
- Na, Jianbo
- Bataille, Veronique
- Cousminer, Diana L.
- Dastani, Zari
- Drong, Alexander W.
- Esko, Tonu
- Evans, David M.
- Falchi, Mario
- Feitosa, Mary F.
- Ferreira, Teresa
- Hedman, Asa K.
- Haring, Robin
- Hysi, Pirro G.
- Iles, Mark M.
- Justice, Anne E.
- Kanoni, Stavroula
- Lagou, Vasiliki
- Li, Rui
- Li, Xin
- Locke, Adam
- Lu, Chen
- Mägi, Reedik
- Perry, John R. B.
- Pers, Tune H.
- Qi, Qibin
- Sanna, Marianna
- Schmidt, Ellen M.
- Scott, William R.
- Shungin, Dmitry
- Teumer, Alexander
- Vinkhuyzen, Anna A. E.
- Walker, Ryan W.
- Westra, Harm-Jan
- Zhang, Mingfeng
- Zhang, Weihua
- Zhao, Jing Hua
- Zhu, Zhihong
- Afzal, Uzma
- Ahluwalia, Tarunveer Singh
- Bakker, Stephan J. L.
- Bellis, Claire
- Bonnefond, Amélie
- Borodulin, Katja
- Buchman, Aron S.
- Cederholm, Tommy
- Choh, Audrey C.
- Choi, Hyung Jin
- Curran, Joanne E.
- de Groot, Lisette C. P. G. M.
- De Jager, Philip L.
- Dhonukshe-Rutten, Rosalie A. M.
- Enneman, Anke W.
- Eury, Elodie
- Evans, Daniel S.
- Forsen, Tom
- Friedrich, Nele
- Fumeron, Frédéric
- Garcia, Melissa E.
- Gärtner, Simone
- Han, Bok-Ghee
- Havulinna, Aki S.
- Hayward, Caroline
- Hernandez, Dena
- Hillege, Hans
- Ittermann, Till
- Kent, Jack W.
- Kolcic, Ivana
- Laatikainen, Tiina
- Lahti, Jari
- Leach, Irene Mateo
- Lee, Christine G.
- Lee, Jong-Young
- Liu, Tian
- Liu, Youfang
- Lobbens, Stephane
- Loh, Marie
- Lyytikäinen, Leo-Pekka
- Medina-Gomez, Carolina
- Michaelsson, Karl
- Nalls, Mike A.
- Nielson, Carrie M.
- Oozageer, Laticia
- Pascoe, Laura
- Paternoster, Lavinia
- Polasek, Ozren
- Ripatti, Samuli
- Sarzynski, Mark A.
- Shin, Chan Soo
- Narancic, Nina Smolej
- Spira, Dominik
- Srikanth, Priya
- Steinhagen-Thiessen, Elisabeth
- Sung, Yun Ju
- Swart, Karin M. A.
- Taittonen, Leena
- Tanaka, Toshiko
- Tikkanen, Emmi
- Velde, Nathalie van der
- Schoor, Natasja M. van
- Verweij, Niek
- Wright, Alan F.
- Yu, Lei
- Zmuda, Joseph M.
- Eklund, Niina
- Forrester, Terrence
- Grarup, Niels
- Jackson, Anne U.
- Kristiansson, Kati
- Kuulasmaa, Teemu
- Kuusisto, Johanna
- Lichtner, Peter
- Luan, Jian'an
- Mahajan, Anubha
- Männistö, Satu
- Palmer, Cameron D.
- Ried, Janina S.
- Scott, Robert A.
- Stancáková, Alena
- Wagner, Peter J.
- Demirkan, Ayse
- Döring, Angela
- Gudnason, Vilmundur
- Kiel, Douglas P.
- Kühnel, Brigitte
- Mangino, Massimo
- Mcknight, Barbara
- Menni, Cristina
- O'Connell, Jeffrey R.
- Oostra, Ben A.
- Shuldiner, Alan R.
- Song, Kijoung
- Vandenput, Liesbeth
- Duijn, Cornelia M. van
- Vollenweider, Peter
- White, Charles C.
- Boehnke, Michael
- Boettcher, Yvonne
- Cooper, Richard S.
- Forouhi, Nita G.
- Gieger, Christian
- Grallert, Harald
- Hingorani, Aroon
- Jorgensen, Torben
- Jousilahti, Pekka
- Kivimaki, Mika
- Kumari, Meena
- Laakso, Markku
- Langenberg, Claudia
- Linneberg, Allan
- Luke, Amy
- Mckenzie, Colin A.
- Palotie, Aarno
- Pedersen, Oluf
- Peters, Annette
- Strauch, Konstantin
- Tayo, Bamidele O.
- Wareham, Nicholas J.
- Bennett, David A.
- Bertram, Lars
- Blangero, John
- Blüher, Matthias
- Bouchard, Claude
- Campbell, Harry
- Cho, Nam H.
- Cummings, Steven R.
- Czerwinski, Stefan A.
- Demuth, Ilja
- Eckardt, Rahel
- Eriksson, Johan G.
- Ferrucci, Luigi
- Franco, Oscar H.
- Froguel, Philippe
- Gansevoort, Ron T.
- Hansen, Torben
- Harris, Tamara B.
- Hastie, Nicholas
- Heliövaara, Markku
- Hofman, Albert
- Jordan, Joanne M.
- Jula, Antti
- Kähönen, Mika
- Kajantie, Eero
- Knekt, Paul B.
- Koskinen, Seppo
- Kovacs, Peter
- Lehtimäki, Terho
- Lind, Lars
- Liu, Yongmei
- Orwoll, Eric S.
- Osmond, Clive
- Perola, Markus
- Pérusse, Louis
- Raitakari, Olli T.
- Rankinen, Tuomo
- Rao, D. C.
- Rice, Treva K.
- Rivadeneira, Fernando
- Rudan, Igor
- Salomaa, Veikko
- Sorensen, Thorkild I. A.
- Stumvoll, Michael
- Tönjes, Anke
- Towne, Bradford
- Tranah, Gregory J.
- Tremblay, Angelo
- Uitterlinden, Andre G.
- Harst, Pim van der
- Vartiainen, Erkki
- Viikari, Jorma S.
- Vitart, Veronique
- Vohl, Marie-Claude
- Völzke, Henry
- Walker, Mark
- Wallaschofski, Henri
- Wild, Sarah
- Wilson, James F.
- Yengo, Loic
- Bishop, D. Timothy
- Borecki, Ingrid B.
- Chambers, John C.
- Cupples, L. Adrienne
- Dehghan, Abbas
- Deloukas, Panos
- Fatemifar, Ghazaleh
- Fox, Caroline
- Furey, Terrence S.
- Franke, Lude
- Han, Jiali
- Hunter, David J.
- Karjalainen, Juha
- Karpe, Fredrik
- Kaplan, Robert C.
- Kooner, Jaspal S.
- McCarthy, Mark I.
- Murabito, Joanne M.
- Morris, Andrew P.
- Bishop, Julia A. N.
- North, Kari E.
- Ohlsson, Claes
- Ong, Ken K.
- Prokopenko, Inga
- Richards, J. Brent
- Schadt, Eric E.
- Spector, Tim D.
- Widén, Elisabeth
- Willer, Cristen J.
- Yang, Jian
- Ingelsson, Erik
- Mohlke, Karen L.
- Hirschhorn, Joel N.
- Pospisilik, John Andrew
- Zillikens, M. Carola
- Lindgren, Cecilia
- Kilpeläinen, Tuomas Oskari
- Loos, Ruth J. F.
Publication date
January 2016
DOI Publisher
Ludwig-Maximilians-Universität München Language
EnglishAbstract
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P < 5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed dist...
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