Germline mutations in the DNA damage response genes BRCA1, BRCA2, BARD1 and TP53 in patients with therapy related myeloid neoplasms
- Schulz, Eduard
- Valentin, Angelika
- Ulz, Peter
- Beham-Schmid, Christine
- Lind, Karin
- Rupp, Verena
- Lackner, Herwig
- Wölfler, Albert
- Zebisch, Armin
- Olipitz, Werner
- Geigl, Jochen
- Berghold, Andrea
- Speicher, Michael R.
- Sill, Heinz
Publication date
July 2012
DOI Publisher
Ludwig-Maximilians-Universität München Language
EnglishAbstract
Therapy related myeloid neoplasms (t-MNs) are complex diseases originating from an interplay between exogenous toxicities and a susceptible organism. It has been hypothesised that in a subset of cases t-MNs develop in the context of hereditary cancer predisposition syndromes
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