The canine heartworm (Dirofilaria immitis) is a mosquito-borne parasitic nematode whose range is extending due to climate change. In a four-dimensional analysis involving HPLC, MALDI-TOF-MS and MS/MS in combination with chemical and enzymatic digestions, we here reveal an N-glycome of unprecedented complexity. We detect N-glycans of up to 7000 Da, which contain long fucosylated HexNAc-based repeats, as well as glucuronylated structures. While some modifications including LacdiNAc, chitobiose, α1,3-fucose and phosphorylcholine are familiar, anionic N-glycans have previously not been reported in nematodes. Glycan array data show that the neutral glycans are preferentially recognised by IgM in dog sera or by mannose binding lectin when antenna...
Millions of people worldwide are infected with filarial nematodes, responsible for lymphatic filaria...
ES-62 is the major secreted product of the parasitic filarial nematode Acanthocheilonema viteae and ...
Glycan molecules from helminth parasites have been associated with diverse biological functions rang...
The canine heartworm (Dirofilaria immitis) is a mosquito-borne parasitic nematode whose range is ext...
AbstractParasitic nematodes infect billions of people world-wide, often causing chronic infections a...
Serum N-glycan profiling studies during the past decades have shown robust associations between N-gl...
A major surface constituent of Echinococcus multilocularis adult worms, referred to as EmA9 antigen,...
Glycoconjugates play a crucial role in the host-parasite relationships of helminthic infections, inc...
Caenorhabditis elegans is a genetically well-studied model nematode or “worm”; however, its N-glycom...
Highly modified and immunoactive N-glycans of the canine heartworm, Nature Communications, 2019zip a...
N-glycosylation has remained mostly unexplored in Piroplasmida, an order of tick-transmitted pathoge...
Nematodes are one of the largest groups of animals on the planet. Many of them are major pathogens o...
Helminth parasites secrete a wide variety of immunomodulatory proteins and lipids to dampen host imm...
AbstractGlycan molecules from helminth parasites have been associated with diverse biological functi...
Heartworm disease, caused by Dirofilaria immitis, remains a significant threat to canines and feline...
Millions of people worldwide are infected with filarial nematodes, responsible for lymphatic filaria...
ES-62 is the major secreted product of the parasitic filarial nematode Acanthocheilonema viteae and ...
Glycan molecules from helminth parasites have been associated with diverse biological functions rang...
The canine heartworm (Dirofilaria immitis) is a mosquito-borne parasitic nematode whose range is ext...
AbstractParasitic nematodes infect billions of people world-wide, often causing chronic infections a...
Serum N-glycan profiling studies during the past decades have shown robust associations between N-gl...
A major surface constituent of Echinococcus multilocularis adult worms, referred to as EmA9 antigen,...
Glycoconjugates play a crucial role in the host-parasite relationships of helminthic infections, inc...
Caenorhabditis elegans is a genetically well-studied model nematode or “worm”; however, its N-glycom...
Highly modified and immunoactive N-glycans of the canine heartworm, Nature Communications, 2019zip a...
N-glycosylation has remained mostly unexplored in Piroplasmida, an order of tick-transmitted pathoge...
Nematodes are one of the largest groups of animals on the planet. Many of them are major pathogens o...
Helminth parasites secrete a wide variety of immunomodulatory proteins and lipids to dampen host imm...
AbstractGlycan molecules from helminth parasites have been associated with diverse biological functi...
Heartworm disease, caused by Dirofilaria immitis, remains a significant threat to canines and feline...
Millions of people worldwide are infected with filarial nematodes, responsible for lymphatic filaria...
ES-62 is the major secreted product of the parasitic filarial nematode Acanthocheilonema viteae and ...
Glycan molecules from helminth parasites have been associated with diverse biological functions rang...