Abstract BACKGROUND: MHC class II deficiency leads to defective CD4+ T-cell function that results from impaired antigen presentation. A genetic disorder in 1 of 4 genes results in this syndrome that is associated with the clinical phenotype of combined immunodeficiency. OBJECTIVE: To describe the clinical, immunological, and molecular characteristics of 10 Egyptian patients from 9 different families having presented with MHC class II deficiency between 2012 and 2017. METHODS: An initial diagnosis based on the combination of clinical features and low HLA-DR expression by flow cytometry was confirmed by genetic analyses. RESULTS: Symptoms included failure to thrive (n = 9), persistent diarrhea (n = 5), and pneumonia (n = 8). Septicemia du...
Background: Tuberculosis remains a major health problem in developing countries especially with the ...
Major histocompatibility complex class II (MHCII) deficiency is a primary immunodeficiency resulting...
Severe combined immunodeficiency (SCID) is fatal if not treated with immune reconstitution. In Egypt...
Abstract BACKGROUND: MHC class II deficiency leads to defective CD4+ T-cell function that results f...
PurposeMajor histocompatibility complex class II (MHC-II) deficiency is a rare inborn error of immun...
The MHC II deficiency is a rare autosomal recessive primary immunodeficiency syndrome with increased...
The MHC II deficiency is a rare autosomal recessive primary immunodeficiency syndrome with increase...
Major histocompatibility complex (MHC) class II deficiency is a rare autosomal recessive form of pri...
BACKGROUND: Major-histocompatibility-complex (MHC) class II deficiency is an autosomal recessive pri...
PubMed ID: 25702838Background Most patients with MHC class I (MHC-I) deficiency carry genetic defect...
The class II major histocompatibility complex antigen deficiency syndrome is a rare immunodeficiency...
Background: Combined immunodeficiencies (CIDs) are diseases of defective adaptive immunity with dive...
LPS-responsive beige-like anchor (LRBA) deficiency is an autosomal recessive primary immunodeficienc...
Objective: To present the genetic causes of patients with primary immune deficiencies (PIDs) in Kuwa...
Expression of major histocompatibility complex (MHC) class II genes is controlled at the transcripti...
Background: Tuberculosis remains a major health problem in developing countries especially with the ...
Major histocompatibility complex class II (MHCII) deficiency is a primary immunodeficiency resulting...
Severe combined immunodeficiency (SCID) is fatal if not treated with immune reconstitution. In Egypt...
Abstract BACKGROUND: MHC class II deficiency leads to defective CD4+ T-cell function that results f...
PurposeMajor histocompatibility complex class II (MHC-II) deficiency is a rare inborn error of immun...
The MHC II deficiency is a rare autosomal recessive primary immunodeficiency syndrome with increased...
The MHC II deficiency is a rare autosomal recessive primary immunodeficiency syndrome with increase...
Major histocompatibility complex (MHC) class II deficiency is a rare autosomal recessive form of pri...
BACKGROUND: Major-histocompatibility-complex (MHC) class II deficiency is an autosomal recessive pri...
PubMed ID: 25702838Background Most patients with MHC class I (MHC-I) deficiency carry genetic defect...
The class II major histocompatibility complex antigen deficiency syndrome is a rare immunodeficiency...
Background: Combined immunodeficiencies (CIDs) are diseases of defective adaptive immunity with dive...
LPS-responsive beige-like anchor (LRBA) deficiency is an autosomal recessive primary immunodeficienc...
Objective: To present the genetic causes of patients with primary immune deficiencies (PIDs) in Kuwa...
Expression of major histocompatibility complex (MHC) class II genes is controlled at the transcripti...
Background: Tuberculosis remains a major health problem in developing countries especially with the ...
Major histocompatibility complex class II (MHCII) deficiency is a primary immunodeficiency resulting...
Severe combined immunodeficiency (SCID) is fatal if not treated with immune reconstitution. In Egypt...