Stress-inducible-stem cells: a new view on endocrine, metabolic and mental disease?

“Stress may be defined as a mechanism of acute and chronic adaptation necessary for evolution and survival. The integrated stress response is part of the homoeostatic balance, and dysfunction of such response may contribute to disease. Alternations of the endocrine, neural and immune responses to stress are involved both in etiology and the pathophysiology of the most common health problems in modern society.” (World Health Organization_WHO/RPS/98.3)