Metastatic acral lentiginous melanoma in a tertiary referral center in Switzerland: a systematic analysis
- Häfliger, Esther M
- Ramelyte, Egle
- Mangana, Joanna
- Kunz, Michael
- Kazakov, Dmitry V
- Dummer, Reinhard
- Cheng, Phil F
DOIAbstract
Acral lentiginous melanoma (ALM) is a unique histopathological subtype of melanoma with a poorer prognosis than other cutaneous melanomas. This study aims to evaluate the clinicopathological characteristics, metastatic pattern, prognostic factors, response to systemic therapy, and overall survival (OS) of ALM in a White population. This is a retrospective study of patients who were diagnosed and/or treated for ALM at the Department of Dermatology of the University Hospital Zurich, Switzerland, from January 2005 to December 2015. Overall, 172 patients with histologically confirmed ALM were included in the study. In univariate Cox regression, Breslow thickness (P<0.001), age (P=0.003), status of sentinel lymph node (P=0.005), and ulceration (...
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