Effect of magnesium sulfate on hemodynamic response to endotracheal intubation and carbon dioxide pneumoperitoneum in laparoscopic cholecystectomy

Abstract: Background: Endotracheal intubation and carbon dioxide pneumoperitoneum in patients undergoing laparoscopic cholecystectomy changes hemodynamic parameters. According to magnesium effect on the inhibition of catecholamine release and attenuate vasopressin-stimulated vasoconstriction, this study was performed to reduce the hemodynamic effects during tracheal intubation and pneumoperitoneum in patients undergoing laparoscopic cholecystectomy. Material and methods: In prospective triple-blind clinical trial, 60 patients 18- 70 years old undergoing laparoscopic cholecystectomy were randomly assigned to one of two groups: intervention group (30 mg/kg magnesium sulfate) and control group (1.5 mg/kg lidocaine). Heart rate and mean arterial pressure were recorded before laryngoscopy (baseline value), immediately and every minute after intubation until 5 minute and before and 5, 10, 15, 30 min after pneumoperitoneum. Results: Mean arterial pressure was low in magnesium sulfate group than control group throughout the study period and was statistically significant at before insufflation and 5 minute after insufflation (p=0.005). Heart rate in magnesium sulfate group was higher than control group throughout the study period (P>0.05). Conclusion: Using magnesium sulfate 30 mg/kg in patients undergoing laparoscopic cholecystectomy can attenuate mean arterial pressure change in pneumoperitoneum than lidocaine