Investigating Prevalence of Mycoplasma hominis Infection in Pregnant Women with Premature preterm rupture of membrane (PPROM) and it’s neonatal effect

Background and Objective: Preterm prelabor rupture of membranes (PPROM),is defined as rupture of thefetal membranes with before the onset of regular uterine contractions before completed weeks 37 of gestation, and represents aserious perinatal problem. The purpose of this study was to evaluate the prevalence of cervical colonization by Mycoplasma hominis in patients with preterm premature rupture of the membranes (PPROM). methods: We studied 160 women between 25 and 37 weeks of gestation with PPROM. Cervical swabs were obtained for genital mycoplasmas and assessed by PCR. In the control group were 160 women with a normal pregnancy without preterm labor. Results: Mycoplasma hominis was detected in 17.5 % (28/160) of the patients with PPROM. In the control group Mycoplasma hominis was detected in 6.3 % (10/160) pregnant women. The results of the odds ratio test showed that the odds ratio of Mycoplasma hominis infection in patients with PPROM was 3.18 times more than of pregnant women without PPROM, and the chance of developing RDS in infant In mothers with PPROM, was 3.71 times more than of pregnant women who have no PPROM. Conclusion: Our results provide evidence of an association between cervical colonization with genital mycoplasmas and preterm premature rupture of the membranes