Transfusion-transmitted hepatitis E in Germany, 2013
- Huzly, D.
- Umhau, M.
- Bettinger, D.
- Cathomen, T.
- Emmerich, F.
- Hasselblatt, P.
- Hengel, H.
- Herzog, R.
- Kappert, O.
- Maassen, S.
- Schorb, E.
- Schulz-Huotari, C.
- Thimme, R.
- Unmussig, R.
- Wenzel, Jürgen J.
- Panning, M.
Publication date
January 2014
DOIAbstract
The reported IgG seroprevalence against hepatitis E virus (HEV) in German blood donations is 6.8%, and HEV RNA detected in 0.08%, but documented evidence for HEV transmission is lacking. We identified two donations from a single donor containing 120 IU HEV RNA/mL plasma and 490 IU/mL. An infectious dose of 7,056 IU HEV RNA was transmitted via apheresis platelets to an immunosuppressed patient who developed chronic HEV. Further, transmission was probable in an immunocompetent child
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