Our studies revealed that lithocholic acid (LCA), a bile acid, is a potent anti‐aging natural compound that in yeast cultured under longevity‐extending caloric restriction (CR) conditions acts in synergy with CR to enable a significant further increase in chronological lifespan. Here, we investigate a mechanism underlying this robust longevity‐extending effect of LCA under CR. We found that exogenously added LCA enters yeast cells, is sorted to mitochondria, resides mainly in the inner mitochondrial membrane, and also associates with the outer mitochondrial membrane. LCA elicits an age‐related remodeling of glycerophospholipid synthesis and movement within both mitochondrial membranes, thereby causing substantial changes in mitochondrial m...
We would like to acknowledge the BSU staff for their invaluable help with caring for the animals. Th...
ATRX is an ATP‐dependent chromatin remodeler required for the maintenance of genomic integrity. We p...
Aged testes undergo profound histological and morphological alterations leading to a reduced functio...
In the fission yeast Schizosaccharomyces pombe, the stationary phase‐specific transcription factor P...
In chronologically aging yeast, longevity can be extended by administering a caloric restriction (CR...
In the last few decades, a large body of experimental evidence has highlighted the complex role for ...
Inhibition of growth signaling pathways protects against aging and age-related diseases in parallel ...
An altered metabolism is involved in the development of clear cell - renal cell carcinoma (ccRCC), a...
An altered metabolism is involved in the development of clear cell - renal cell carcinoma (ccRCC), a...
The eukaryotic glyoxalase system consists of two enzymatic components, glyoxalase I (lactoylglutathi...
Malnutrition is common among older persons, with important consequences increasing frailty and morbi...
Aging is the main risk factor for most chronic diseases. Epigenetic mechanisms, such as DNA methylat...
Malnutrition is common among older persons, with important consequences increasing frailty and morbi...
Mitochondria have been considered for long time as important determinants of cell aging because of t...
Here, we performed high-throughput drug-screening to identify new non-toxic mitochondrial inhibitors...
We would like to acknowledge the BSU staff for their invaluable help with caring for the animals. Th...
ATRX is an ATP‐dependent chromatin remodeler required for the maintenance of genomic integrity. We p...
Aged testes undergo profound histological and morphological alterations leading to a reduced functio...
In the fission yeast Schizosaccharomyces pombe, the stationary phase‐specific transcription factor P...
In chronologically aging yeast, longevity can be extended by administering a caloric restriction (CR...
In the last few decades, a large body of experimental evidence has highlighted the complex role for ...
Inhibition of growth signaling pathways protects against aging and age-related diseases in parallel ...
An altered metabolism is involved in the development of clear cell - renal cell carcinoma (ccRCC), a...
An altered metabolism is involved in the development of clear cell - renal cell carcinoma (ccRCC), a...
The eukaryotic glyoxalase system consists of two enzymatic components, glyoxalase I (lactoylglutathi...
Malnutrition is common among older persons, with important consequences increasing frailty and morbi...
Aging is the main risk factor for most chronic diseases. Epigenetic mechanisms, such as DNA methylat...
Malnutrition is common among older persons, with important consequences increasing frailty and morbi...
Mitochondria have been considered for long time as important determinants of cell aging because of t...
Here, we performed high-throughput drug-screening to identify new non-toxic mitochondrial inhibitors...
We would like to acknowledge the BSU staff for their invaluable help with caring for the animals. Th...
ATRX is an ATP‐dependent chromatin remodeler required for the maintenance of genomic integrity. We p...
Aged testes undergo profound histological and morphological alterations leading to a reduced functio...