The prognostic value of P53 in patients with prostate cancer after radical prostatectomy

Tzelepis, Vasileios
Τζελέπης, Βασίλειος

Open link

Publication date

January 2013

DOI

10.12681/eadd/41704

Publisher

National Documentation Centre (EKT)

Abstract

Objective: This study assesses the correlation of p53 immunoreactivity andp21 immunoreactivity with biochemical recurrence after radicalprostatectomy.Materials and Methods: P53 protein expression and p21 were evaluated on84 archival paraffin-embedded radical prostatectomy specimens. Patientswere divided into 2 groups for p533: patients with low (38/84, 45%) andpatients with high (46/84, 55%) p53 immunoreactivity and into 5 groups forp21. Patients with expression of p21<1%, patients with p21 expressionbetween 1 and 5%, patients with p21 expression between 5 and 10%,patients with p21 expression between 10 and 20% and finally patients withp21 expression over 20%. The results were correlated with Gleason score,DNA ploidy, stage and serum PSA. K...