Correlation between prognostic significance and biological behaviour of sanamous cell carcinoma of tongue with apoptosis of malignant cells
- Andressakis, Dionysios
- Ανδρεσάκης, Διονύσιος
DOIAbstract
Apoptosis is a programmed cell death process, which regulates tissue homeostasis even from the embryonic life. Imbalances in apoptotic cell death genes combined with telomerase over expression and alterations of the cell cycle lead to a progressive loss of tissue homeostasis reflecting the inability of cells to respond to normal apoptotic death signals. Down regulation of apoptotic proteins, such as caspases combined to up regulation of anti-apoptotic factors, such as bcl2, bcl x and survivin is responsible for excessive proliferation, inhibition of apoptosis and also for chemoresistance in cancers of different origin. The main aim was to investigate the potential role of caspase-3 and caspase-8 protein expression in the biological behaviou...