PARALIPOPROTEINS IN MULTIPLE MYELOMA.

ΕΚ ΤΗΣ ΜΕΛΕΤΗΣ ΤΩΝ ΛΙΠΟΠΡΩΤΕΙΝΩΝ ΚΑΙ ΤΩΝ ΛΙΠΙΔΙΩΝ ΤΟΥ ΠΛΑΣΜΑΤΟΣ ΕΠΙ ΕΙΚΟΣΙΔΥΟ (22) ΑΤΟΜΩΝ ΠΑΣΧΟΝΤΩΝ ΕΚ ΔΙΑΦΟΡΩΝ ΤΥΠΩΝ ΠΟΛΛΑΠΛΟΥ ΜΥΕΛΩΜΑΤΟΣ ΠΡΟΕΚΥΨΑΝ ΤΑ ΚΑΤΩΘΙ: Α) ΚΑΤΑ ΤΗΝ ΗΛΕΚΤΡΟΦΟΡΗΣΙΝ ΤΩΝ ΛΙΠΟΠΡΩΤΕΙΝΩΝ ΕΠΙ ΑΓΑΡΟΖΗΣ 1% ΔΙΕΠΙΣΤΩΘΗ ΕΙΣ ΔΕΚΑΟΚΤΩ (18) ΕΚ ΤΩΝ ΕΙΚΟΣΙΔΥΟ (22) ΑΣΘΕΝΩΝ Η ΠΑΡΟΥΣΙΑ ΠΑΘΟΛΟΓΙΚΩΝ ΛΙΠΟΠΡΩΤΕΙΝΙΚΩΝ ΚΛΑΣΜΑΤΩΝ, ΚΑΛΟΥΜΕΝΩΝ "ΠΑΡΑΛΙΠΟΠΡΩΤΕΙΝΩΝ", ΕΧΟΝΤΩΝ ΚΙΝΗΤΙΚΟΤΗΤΑ ΟΜΟΙΑΝΤΗΣ ΠΑΡΑΠΡΩΤΕΙΝΗΣ ΚΑΙ ΔΗ ΣΥΓΚΕΚΡΙΜΕΝΩΣ Η ΠΑΡΟΥΣΙΑ: Α) ΚΛΑΣΜΑΤΟΣ ΚΙΝΗΤΙΚΟΤΗΤΟΣ Γ - ΣΦΑΙΡΙΝΗΣ ΚΑΙ ΠΥΚΝΟΤΗΤΟΣ ΜΕΓΑΛΥΤΕΡΑΣ ΤΟΥ 1.063 GR/ML. Β) ΚΛΑΣΜΑΤΟΣ ΚΙΝΗΤΙΚΟΤΗΤΟΣ ΠΑΡΟΜΟΙΑΣ ΠΕΡΙΠΟΥ ΑΥΤΗΣ ΤΩΝ ΧΥΛΟΜΙΚΡΩΝ ΚΑΙ ΠΥΚΝΟΤΗΤΟΣ ΜΕΓΑΛΥΤΕΡΑΣ ΤΟΥ1.063 GR/ML. Γ) ΚΛΑΣΜΑΤΟΣ ΚΙΝΗΤΙΚΟΤΗΤΟΣ Β - ΣΦΑΙΡΙΝΗΣ. Β) Η ΧΟΛΗΣΤΕΡΙΝΗ ΚΑΙ ΤΑ ΤΡΙΓΛΥΚΕΡΙΔΙΑ ΤΟΥ ΠΛΑΣΜΑΤΟΣ ΤΩΝ ΩΣ ΑΝΩ ΜΕΛΕΤΗΘΕΝΤΩΝ ΑΣΘΕΝΩΝ ΑΝΕΥΡΕΘΗΣΑΝ ΕΙΣ ΦΥΣΙΟΛΟΓΙΚΑ ΕΠΙΠΕΔΑ, ΠΛΗΝ ΜΙΑΣ ΠΕΡΙΠΤΩΣΕΩΣ ΚΑΤΑ ΤΗΝ ΟΠΟΙΑΝ ΑΝΕΥΡΕΘΗ ΜΕΤΡΙΑ ΑΥΞΗΣΙΣ ΤΩΝ ΤΡΙΓΛΥΚΕΡΙΔΙΩΝ ΤΟΥ ΠΛΑΣΜΑΤΟΣ.IN THE PRESENT WORK THE LIPID AND LIPOPROTEIN PATTERN IN MULTIPLE MYELOMA WAS INVESTIGATED. IN THE FIRST PART THE PERTINENT DATA OF THE LITERATURE CONCERNINGTHE STRUCTURE AND METABOLISM OF LIPOPROTEINS ARE REVIEWED. THE SECOND PART OF THIS WORK DEALS WITH THE STUDY OF CHOLESTEROL AND TRIGLYCERIDE LEVELS, AS WELL AS WITH THE LIPOPROTEIN PATTERN OF TWENTY TWO (22) PATIENTS WITH VARIOUS TYPES OF MULTIPLE MYELOMA. THE MATERIAL AND METHODS OF STUDY, THE DESCRIPTION AND DISCUSSION OF RESULTS COME UNDER SEPARATE HEADINGS. THE RESULTS OF THIS WORK ARE AS FOLLOWS: 1) LIPOPROTEIN ELECTROPHORESIS ON 1% AGAROSE GEL SHOWED THE PRESENCE OF ABNORMAL LIPOPROTEINS WITH DIFFERENT MOBILITY IN EIGHTEEN (18) OUT OF THE TWENTY TWO (22) PATIENTS INVESTIGATED. THE ABNORMAL LIPOPROTEINS COULD BE GROUPED IN THE ONE OF THE FOLLLOWING FRACTIONS. A) THE PARALIPOPROTEIN FRACTION P.L.P1, WITH A MOBILITY SIMILAR TO THAT OF Γ - GLOBULIN AND DENSITY OVER 1063 GR/ML. B) THE PARALIPOPROTEIN FRACTION P.L.P2, WITH A MOBILITY SIMILAR TO THAT OF THE CHYLOMICRONS (BETWEEN Β - Γ GLOBULINS) AND A DENSITY OVER1063 GR/ML. C) THE PARALIPOPROTEIN FRACTION P.L.P3, WITH A MOBILITY SIMILAR TO THAT OF Β - GLOBULIN. IN THE THREE LIPOPROTEIN FRACTIONS DESCRIBED ABOVE THE PARAPROTEIN SEEMS TO ACT AS AN APOLIPOPROTEIN. THE PARAPROTEIN IS BOUND TO VARYING AMOUNTS OF LIPIDS, IN THE ABOVE CASES AS SHOWN BY THIN LAYER CHROMATOGRAPHY. IN FOUR (4) CASES NO ABNORMAL LIPOPROTEIN WAS FOUND IN THE PLASMA, DESPITE THE PRESENCE OF PARAPROTEIN. IT WAS SUGGESTED THAT THIS MAY BE DUE TO EITHER TO SMALL QUANTITIES OF (ABSTRACT TRUNCATED