ISOFLURANE IN NEUROSURGERY ANESTHETIC

ISOFLURANE IS CONSIDERED AS SUPERIOR TO OTHER VOLATIL AND GASEOUS ANAESTHETICS FOR NEUROSURGERY, ESPECIALLY WITH REGARDS TO ITS PHYSICOCHEMICAL PROPERTIES AND TO ITS METABOLISM. TWENTY PATIENTS, MIDDLE AGED 58 YEARS, II ASA, UNDERGOING CRANIOTOMY FOR INTERCRANIAL NEOPLASM WERE STUDIED. PREMEDICATION WAS FENTANYL AND DROPERIDOL. INDUCTION WAS THIOPENTONE, FENTANYL AND SUCCINYLOCHOLINETO FACILITATE INTUBATION. HYPERVENTILATION, IN ORDER TO ACHIEVE A PACO2 25-30 TORR, BEGAN SIMULTANEOUSLY WITH THE INTRODUCTION OF 1-1,5% ISOFLURANE. WE MONITORED INTRACRANIAL PRESSURE (ICP), CENTRAL VENOUS PRESSURE (CVP), HEART RATE(HR), MEAN ARTERIAL PRESSURE (MAP), BLOOD GASES, END-TIDAL CO2 (ETCO2). ISOFLURANE DID NOT CAUSE ANY SIGNIFICANT CHANGE IN ICP, CVP, AND HR. MAP WAS DECREASED SIGNIFICANT AND THE HIGHER ISOFLURANE CONCENTRATION (P<0,001), PH AND PAO2 WERE NO SIGNIFICANT CHANGED (P