Ultrasound-modulated optical tomography in biological tissue: Theoretical and experimental studies

Ultrasound-modulated optical tomography in biological tissue was studied both theoretically and experimentally. Parallel detection of the speckle field formed by the transmitted laser light was implemented with the source-synchronous-illumination lock-in technique. Two-dimensional images of biological tissue were successfully obtained experimentally with a laser beam of either normal or oblique incidence, which showed that ultrasound-modulated optical tomography depends on diffuse light rather than ballistic light. Monte-Carlo modeling technique was used to simulate the ultrasound-modulated optical tomography