Monoclonal antibodies and other protein therapeutics are rapidly gaining popularity as a favored class of drugs for treatment of various types of diseases and disorders including rheumatoid arthritis, Crohn’s disease, asthma, macular degeneration, different types of cancer. There great lot of interest in development of subcutaneous self-injection methods for administering these therapeutics to enable patient convenience which requires high concentration formulations to deliver the required dosage in the limited volume. At high concentrations, proteins have a propensity to be insoluble, aggregate, unfold, gel or denature due to strong short ranged protein-protein interactions, resulting in highly viscous solutions. Therefore, it is challengi...
High concentration subcutaneous (SC) dosing regimens are desirable for monoclonal antibody (MAb) the...
Wagner, Norman J.Liu, YunColloidal particles and ``soft matter'' materials are essential parts of ma...
Roberts, Christopher J.Robinson, Anne S.Proteins therapeutics have emerged as an important class of ...
Monoclonal antibodies and other protein therapeutics are rapidly gaining popularity as a favored cla...
Stabilizing proteins at high concentration is of broad interest in drug delivery, for treatment of c...
textThe ability to formulate monoclonal antibodies at high concentration in a low-viscosity form is ...
textDelivery of protein therapeutics is restricted to intravenous infusions due to protein-dependent...
Solutions of monoclonal antibodies (mAbs) at high concentration are strongly desirable for subcutane...
Protein-based therapeutics such as monoclonal antibodies (mAbs) and related fragments are increasing...
Concentrated solutions of monoclonal antibodies have attracted considerable attention due to their i...
Although protein based therapeutics is the fastest growing sector of the pharmaceutical industry, pr...
Protein aggregation occurs under certain conditions that cause individual protein sub-units to adher...
The increasing demands for biopharmaceuticals to treat different diseases have raised concerns about...
Highly concentrated (> 200 mg/mL) monoclonal antibody (mAb) formulations with low viscosities are st...
Roberts, Christopher J.The diverse behavior of protein solutions can be attributed to the collection...
High concentration subcutaneous (SC) dosing regimens are desirable for monoclonal antibody (MAb) the...
Wagner, Norman J.Liu, YunColloidal particles and ``soft matter'' materials are essential parts of ma...
Roberts, Christopher J.Robinson, Anne S.Proteins therapeutics have emerged as an important class of ...
Monoclonal antibodies and other protein therapeutics are rapidly gaining popularity as a favored cla...
Stabilizing proteins at high concentration is of broad interest in drug delivery, for treatment of c...
textThe ability to formulate monoclonal antibodies at high concentration in a low-viscosity form is ...
textDelivery of protein therapeutics is restricted to intravenous infusions due to protein-dependent...
Solutions of monoclonal antibodies (mAbs) at high concentration are strongly desirable for subcutane...
Protein-based therapeutics such as monoclonal antibodies (mAbs) and related fragments are increasing...
Concentrated solutions of monoclonal antibodies have attracted considerable attention due to their i...
Although protein based therapeutics is the fastest growing sector of the pharmaceutical industry, pr...
Protein aggregation occurs under certain conditions that cause individual protein sub-units to adher...
The increasing demands for biopharmaceuticals to treat different diseases have raised concerns about...
Highly concentrated (> 200 mg/mL) monoclonal antibody (mAb) formulations with low viscosities are st...
Roberts, Christopher J.The diverse behavior of protein solutions can be attributed to the collection...
High concentration subcutaneous (SC) dosing regimens are desirable for monoclonal antibody (MAb) the...
Wagner, Norman J.Liu, YunColloidal particles and ``soft matter'' materials are essential parts of ma...
Roberts, Christopher J.Robinson, Anne S.Proteins therapeutics have emerged as an important class of ...