This study investigated whether IL-1β and TNF-α have a role in the pathophysiology of seizures by altering neuronal excitability and cell survival and also probed new targets to achieve an effective anticonvulsive action. The first set of experiments evaluated if acute and spontaneous seizures can be effectively inhibited by blocking the brain production of IL-1β using a selective inhibitor of caspase-1, the key enzyme specifically involved in the production of the releasable and biologically active form of IL-1β. Caspase-1 inhibition significantly reduced the number and the total time spent in seizures, indicating that this treatment represents an effective and novel anticonvulsive strategy. The second set of experiments investigat...
Epilepsy is a chronic, common, neurological disorder marked by transient, paroxysmal and hypersynchr...
We recently discovered that forebrain activation of the IL-1 receptor/Toll-like receptor (IL-1R1/TLR...
Epilepsy therapy is based on drugs that treat the symptoms rather than the underlying mechanisms of ...
This study investigated whether IL-1β and TNF-α have a role in the pathophysiology of seizures by al...
Purpose: Cytokines and related inflammatory mediators are rapidly synthesized in the brain during se...
Epilepsy therapy is based on drugs that treat the symptoms, seizures, rather than the disease. There...
A large body of evidence that has accumulated over the past decade strongly supports the role of inf...
International audienceABSTRACT: BACKGROUND: Inflammatory signaling elicited by prolonged seizures ca...
In this exciting era, we are coming closer and closer to bringing an anti‐inflammatory therapy to th...
Besides systemic infection, proinflammatory signals in the CNS are also recruited by epileptic activ...
The paper contains the data related to the authors’ experimental trials, which revealed the influenc...
Summary: Experimental evidence and clinical observations indicate that brain inflammation is an impo...
The overall goal of this thesis was to determine the contribution of endogenous interleukin-1β (IL-1...
dissertationEpilepsy is the fourth most common neurological disorder and is characterized by excessi...
Epilepsy is the most common serious brain disorder worldwide. Recent evidence from experimental mo...
Epilepsy is a chronic, common, neurological disorder marked by transient, paroxysmal and hypersynchr...
We recently discovered that forebrain activation of the IL-1 receptor/Toll-like receptor (IL-1R1/TLR...
Epilepsy therapy is based on drugs that treat the symptoms rather than the underlying mechanisms of ...
This study investigated whether IL-1β and TNF-α have a role in the pathophysiology of seizures by al...
Purpose: Cytokines and related inflammatory mediators are rapidly synthesized in the brain during se...
Epilepsy therapy is based on drugs that treat the symptoms, seizures, rather than the disease. There...
A large body of evidence that has accumulated over the past decade strongly supports the role of inf...
International audienceABSTRACT: BACKGROUND: Inflammatory signaling elicited by prolonged seizures ca...
In this exciting era, we are coming closer and closer to bringing an anti‐inflammatory therapy to th...
Besides systemic infection, proinflammatory signals in the CNS are also recruited by epileptic activ...
The paper contains the data related to the authors’ experimental trials, which revealed the influenc...
Summary: Experimental evidence and clinical observations indicate that brain inflammation is an impo...
The overall goal of this thesis was to determine the contribution of endogenous interleukin-1β (IL-1...
dissertationEpilepsy is the fourth most common neurological disorder and is characterized by excessi...
Epilepsy is the most common serious brain disorder worldwide. Recent evidence from experimental mo...
Epilepsy is a chronic, common, neurological disorder marked by transient, paroxysmal and hypersynchr...
We recently discovered that forebrain activation of the IL-1 receptor/Toll-like receptor (IL-1R1/TLR...
Epilepsy therapy is based on drugs that treat the symptoms rather than the underlying mechanisms of ...