Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the activation of the innate immune adaptor STING (STimulator of INterfern Genes)
International audienceMammalian cells use cytosolic nucleic acid receptors to detect pathogens and o...
The innate immune system detects infection by employing germline-encoded receptors specific for cons...
The production of cytokines by the immune system in response to cytosolic DNA plays an important rol...
Innate immunity is regulated by a broad set of evolutionary conserved receptors to finely probe the ...
Recognition of foreign DNA in intracellular compartments or in the cytoplasm sounds an alarm bell si...
Detection of microbial nucleic acids via innate immune receptors is critical for establishing host d...
The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic GMP–AMP (cGA...
DNA damage can be sensed as a danger-associated molecular pattern by the innate immune system. Here ...
Although it has been appreciated for some years that cytosolic DNA is immune stimulatory, it is only...
Rapid detection of microbes is crucial for eliciting an effective immune response. Innate immune rec...
Published online: 18 September 2020Cytosolic nucleic acid sensors have a critical role in detecting ...
Negative regulation of immune pathways is essential to achieve resolution of immune responses and to...
DNA damage can be sensed as a danger-associated molecular pattern by the innate immune system. Here ...
The cGAS-STING pathway drives innate immune activation in response to cytosolic DNA. This is importa...
It is well known that plasmid DNA transfection, prior to virus infection, negatively affects infecti...
International audienceMammalian cells use cytosolic nucleic acid receptors to detect pathogens and o...
The innate immune system detects infection by employing germline-encoded receptors specific for cons...
The production of cytokines by the immune system in response to cytosolic DNA plays an important rol...
Innate immunity is regulated by a broad set of evolutionary conserved receptors to finely probe the ...
Recognition of foreign DNA in intracellular compartments or in the cytoplasm sounds an alarm bell si...
Detection of microbial nucleic acids via innate immune receptors is critical for establishing host d...
The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic GMP–AMP (cGA...
DNA damage can be sensed as a danger-associated molecular pattern by the innate immune system. Here ...
Although it has been appreciated for some years that cytosolic DNA is immune stimulatory, it is only...
Rapid detection of microbes is crucial for eliciting an effective immune response. Innate immune rec...
Published online: 18 September 2020Cytosolic nucleic acid sensors have a critical role in detecting ...
Negative regulation of immune pathways is essential to achieve resolution of immune responses and to...
DNA damage can be sensed as a danger-associated molecular pattern by the innate immune system. Here ...
The cGAS-STING pathway drives innate immune activation in response to cytosolic DNA. This is importa...
It is well known that plasmid DNA transfection, prior to virus infection, negatively affects infecti...
International audienceMammalian cells use cytosolic nucleic acid receptors to detect pathogens and o...
The innate immune system detects infection by employing germline-encoded receptors specific for cons...
The production of cytokines by the immune system in response to cytosolic DNA plays an important rol...
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