Although the relationship between insulin resistance and cardiovascular diseases is well established, nature and mechanism of the insulin resistance in peripheral tissues is unclear. In this thesis I have demonstrated that a rodent model of genetic hypertension, the stroke-prone spontaneously hypertensive rat (SHRSP), displays resistance to the effects of insulin, characterised by defects at the level of both carbohydrate and lipid metabolism in primary epididymal adipocytes. Insulin-stimulated 2-deoxy-D-glucose uptake is reduced SHRSP compared to Wistar-Kyoto (WKY) control, and there is a profound reduction in the ability of insulin to inhibit isoprenaline-mediated lipolysis. The SHRSP is a relative of the SHR, which develops a similar tho...
SummaryInsulin resistance is a common disorder caused by a wide variety of physiological insults, so...
Indiana University-Purdue University Indianapolis (IUPUI)Insulin resistance, a hallmark of type 2 di...
Indiana University-Purdue University Indianapolis (IUPUI)Insulin resistance starts years before type...
Although the relationship between insulin resistance and cardiovascular diseases is well established...
Insulin resistance is a disease state characterised by the reduced ability of insulin to exert its e...
Insulin resistance in skeletal muscle is of major pathogenic importance in several common human diso...
A hyperglycemic and hyperinsulinemic environment characteristic of type 2 diabetes causes insulin re...
The aim of the present thesis was to further increase our understanding of mechanisms contributing t...
The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes of morbidit...
(Part I.) The purpose of this study was to measure insulin regulated glucose transport and GLUT4 pro...
Peripheral tissue insulin resistance is a key factor in the pathogenesis of type II diabetes mellitu...
Obesity, insulin resistance and hypertension are risk factors for cardiovascular disease which occur...
Insulin orchestrates physiological responses to ingested nutrients, however although it elicits wide...
The metabolic syndrome, a cluster of metabolic derangements that include obesity, glucose intoleranc...
Epidemiological studies have documented a high incidence of diabetes in hypertensive patients.Insuli...
SummaryInsulin resistance is a common disorder caused by a wide variety of physiological insults, so...
Indiana University-Purdue University Indianapolis (IUPUI)Insulin resistance, a hallmark of type 2 di...
Indiana University-Purdue University Indianapolis (IUPUI)Insulin resistance starts years before type...
Although the relationship between insulin resistance and cardiovascular diseases is well established...
Insulin resistance is a disease state characterised by the reduced ability of insulin to exert its e...
Insulin resistance in skeletal muscle is of major pathogenic importance in several common human diso...
A hyperglycemic and hyperinsulinemic environment characteristic of type 2 diabetes causes insulin re...
The aim of the present thesis was to further increase our understanding of mechanisms contributing t...
The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes of morbidit...
(Part I.) The purpose of this study was to measure insulin regulated glucose transport and GLUT4 pro...
Peripheral tissue insulin resistance is a key factor in the pathogenesis of type II diabetes mellitu...
Obesity, insulin resistance and hypertension are risk factors for cardiovascular disease which occur...
Insulin orchestrates physiological responses to ingested nutrients, however although it elicits wide...
The metabolic syndrome, a cluster of metabolic derangements that include obesity, glucose intoleranc...
Epidemiological studies have documented a high incidence of diabetes in hypertensive patients.Insuli...
SummaryInsulin resistance is a common disorder caused by a wide variety of physiological insults, so...
Indiana University-Purdue University Indianapolis (IUPUI)Insulin resistance, a hallmark of type 2 di...
Indiana University-Purdue University Indianapolis (IUPUI)Insulin resistance starts years before type...