The amphidinolides are macrolide natural products isolated from marine dinoflagellates of the genus Amphidinium and most of them display potent cytotoxic activities in vitro. Amphidinolides C-C3, F and T1-5 represent attractive synthetic targets due to a combination of potent bioactivity and complex molecular architecture. This thesis describes the total syntheses of amphidinolides T1, T3 and T4, and the preparation of the C1-C17 fragment of amphidinolides C and F. Concise and high-yielding total syntheses of amphidinolides T1, T3, and T4 have been completed using an alkynyl macrolactone as a common late-stage intermediate. The α-hydroxy ketone motif was installed by sequential alkyne hydrosilylation, epoxidation, and Fleming–Tamao oxidat...
International audienceA new and efficient convergent approach toward the synthesis of amphidinolide ...
The synthesis of the C(18)-C(34) fragment of amphidinolide C has been achieved via two routes, culmi...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2010.Vita. Cataloged fro...
The amphidinolides are marine macrolides extracted from dinoflagellates of the genus Amphidinium. To...
Amphidinolides T are challenging natural targets for the total synthesis community because of their ...
Amphidinolide natural products are a family of marine macrolides, isolated from Amphidinium dinoflag...
The amphidinolides are a family of structurally-related cytotoxic natural products which have shown ...
A formal total synthesis of the cytotoxic macrolide amphidinolide E is reported. The strategic steps...
Exploration of an ambitious new strategy for the total synthesis of the cytotoxic marine natural pro...
The general objective of my thesis work was to achieve the synthesis of amphidinolides C2 and U, mar...
L'objectif général de mon travail de thèse a été de réaliser la synthèse des amphidinolides C2 et U,...
Nature is a pretty unselective “chemist” when it comes to making the highly cytotoxic amphidinolide ...
A convergent synthesis of the C31-C52 bis-tetrahydropyran core of the natural product amphidinol 3 i...
International audienceAmphidinolides F, C, C2, and C3 are marine natural products isolated from dino...
A convergent synthesis of the C31-C52 bis-tetrahydropyran core of the natural product amphidinol 3 i...
International audienceA new and efficient convergent approach toward the synthesis of amphidinolide ...
The synthesis of the C(18)-C(34) fragment of amphidinolide C has been achieved via two routes, culmi...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2010.Vita. Cataloged fro...
The amphidinolides are marine macrolides extracted from dinoflagellates of the genus Amphidinium. To...
Amphidinolides T are challenging natural targets for the total synthesis community because of their ...
Amphidinolide natural products are a family of marine macrolides, isolated from Amphidinium dinoflag...
The amphidinolides are a family of structurally-related cytotoxic natural products which have shown ...
A formal total synthesis of the cytotoxic macrolide amphidinolide E is reported. The strategic steps...
Exploration of an ambitious new strategy for the total synthesis of the cytotoxic marine natural pro...
The general objective of my thesis work was to achieve the synthesis of amphidinolides C2 and U, mar...
L'objectif général de mon travail de thèse a été de réaliser la synthèse des amphidinolides C2 et U,...
Nature is a pretty unselective “chemist” when it comes to making the highly cytotoxic amphidinolide ...
A convergent synthesis of the C31-C52 bis-tetrahydropyran core of the natural product amphidinol 3 i...
International audienceAmphidinolides F, C, C2, and C3 are marine natural products isolated from dino...
A convergent synthesis of the C31-C52 bis-tetrahydropyran core of the natural product amphidinol 3 i...
International audienceA new and efficient convergent approach toward the synthesis of amphidinolide ...
The synthesis of the C(18)-C(34) fragment of amphidinolide C has been achieved via two routes, culmi...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2010.Vita. Cataloged fro...