Data from: Epilepsy duration and seizure outcome in epilepsy surgery: a systematic review and meta-analysis

Objective: To conduct a systematic review and meta-analysis on the effect of earlier or later resective epilepsy surgery on seizure outcome. Methods: We searched the electronic databases PubMed, EMBASE, and Cochrane Library for studies investigating the association of epilepsy duration and seizure freedom after resective surgery. Two reviewers independently screened citations for eligibility and assessed relevant studies for risk of bias. We combined data in meta-analyses using a random effects model. We assessed the certainty of evidence according to grading of recommendations assessment, development and evaluation (GRADE). Results: Twenty-five studies were included, twelve of which had data suitable for meta-analyses. Comparing seizure outcome if epilepsy surgery was performed before versus after 2, 5, 10 and 20 years of epilepsy duration, and comparing epilepsy duration <5 years to >10 years, we found significant effects favoring shorter duration with risk differences (RD) ranging from 0.15 to 0.21 and risk ratios (RR) ranging from 1.20 to 1.33 (p