Data from: Epigenome-wide association study of lung function level and its change
- Imboden, Medea
- Wielscher, Matthias
- Rezwan, Faisal I
- Amaral, Andre F S
- Schaffner, Emmanuel
- Jeong, Ayoung
- Beckmeyer-Borowko, Anna
- Harris, Sarah E
- Starr, John M
- Deary, Ian J
- Flexeder, Claudia
- Waldenberger, Melanie
- Peters, Annette
- Schulz, Holger
- Chen, Su
- Sunny, Shadia KHan
- Karmaus, Wilfried J J
- Jiang, Yu
- Erhart, Gertraud
- Kronenberg, Florian
- Arathimos, Ryan
- Sharp, Gemma C
- Henderson, Alexander John
- Fu, Yu
- Piirila, Paivi
- Pietilainen, Kirsi H
- Ollikainen, Miina
- Johannson, Asa
- Gyllensten, Ulf
- de Vries, Maaike
- van der Plaat, Diana
- de Jong, Kim
- Boezen, Hendrika M
- Hall, Ian P
- Tobin, Martin D
- Järvelin, Marjo-Riitta
- Holloway, John W
- Jarvis, Deborah
- Probst-Hensch, Nicole M
DOIAbstract
Previous reports link differential DNA methylation (DNAme) to environmental exposures which are associated with lung function. Direct evidence on lung function DNAme is however limited. We undertook an agnostic epigenome-wide association study (EWAS) on pre-bronchodilation lung function and its change in adults. In a discovery-replication EWAS design, DNAme in blood and spirometry were measured twice, six-to-15 years apart, in the same participants of three adult population-based discovery cohorts (n=2,043). Associated DNAme markers (P<5x10-7) were tested in seven replication cohorts (adult: n=3,327; childhood: n=420). Technical-bias adjusted residuals of a regression of the normalized absolute beta-values on control-probe-deriv...
Add to ORKG