The generalized moment problem (GMP) is a linear optimization problem over spaces of measures. It allows to model many challenging mathematical problems. While in general it is impossible to solve the GMP, in the case where all data are polynomial and semialgebraic sets, one can define a hierarchy of semidefinite relaxations - the moment-sums-of-squares (moment-SOS) hierachy - which in principle allows to approximate the optimal value of the GMP to arbitrary precision. The work presented in this thesis addresses two facets concerning the GMP and the moment-SOS hierarchy: One facet is concerned with the scalability of relaxations for the GMP. The degree of the SOS weights in the moment-SOS hierarchy grows when augmenting the relaxation order...