Background: Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a Mendelian randomisation (MR) analysis to examine the relationship between adiposity and CRC. Methods: We used SNPs associated with adult body mass index (BMI), waist-hip ratio (WHR), childhood obesity and birth weight as instrumental variables in a MR analysis of 9254 CRC cases and 18 386 controls. Results: In the MR analysis, the odds ratios (ORs) of CRC risk per unit increase in BMI, WHR and childhood obesity were 1.23 (95% CI: 1.02–1.49, P=0.033), 1.59 (95% CI: 1.08–2.34, P=0.019) and 1.07 (95% CI: 1.03–1.13,...
Mechanisms underlying adiposity-colorectal cancer (CRC) association are incompletely understood. Usi...
While elevated blood cholesterol has been associated with an increased risk of colorectal cancer (CR...
BACKGROUND: Epidemiological studies have linked lifestyle, cardiometabolic, reproductive, developmen...
BACKGROUND: Observational studies have associated adiposity with an increased risk of colorectal can...
Background Observational studies have associated adiposity with an increased risk of colorectal canc...
BACKGROUND: High body mass index (BMI) is consistently linked to increased risk of colorectal cancer...
Background: Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relatio...
BACKGROUND: Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relatio...
Background: Adiposity traits have been associated with risk of many cancers in observational studies...
Background: The roles of obesity-related biomarkers and their molecular pathways in the development ...
Adiposity is an established risk factor for colorectal cancer (CRC). However, the pathways underlyin...
Mechanisms underlying adiposity-colorectal cancer (CRC) association are incompletely understood. Usi...
While elevated blood cholesterol has been associated with an increased risk of colorectal cancer (CR...
BACKGROUND: Epidemiological studies have linked lifestyle, cardiometabolic, reproductive, developmen...
BACKGROUND: Observational studies have associated adiposity with an increased risk of colorectal can...
Background Observational studies have associated adiposity with an increased risk of colorectal canc...
BACKGROUND: High body mass index (BMI) is consistently linked to increased risk of colorectal cancer...
Background: Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relatio...
BACKGROUND: Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relatio...
Background: Adiposity traits have been associated with risk of many cancers in observational studies...
Background: The roles of obesity-related biomarkers and their molecular pathways in the development ...
Adiposity is an established risk factor for colorectal cancer (CRC). However, the pathways underlyin...
Mechanisms underlying adiposity-colorectal cancer (CRC) association are incompletely understood. Usi...
While elevated blood cholesterol has been associated with an increased risk of colorectal cancer (CR...
BACKGROUND: Epidemiological studies have linked lifestyle, cardiometabolic, reproductive, developmen...