Repeated chromatographic purifications of aerial parts of the Tunisian plant Daucus virgatus led to the isolation of four new germacranolides, named daucovirgolides I-L (2–5), along with the Plasmodium transmission-blocking agent daucovirgolide G. The chemical structures of the new compounds were defined as mono- or di-angeloylated germacrane-type sesquiterpenoids by spectroscopic (mainly 1D and 2D NMR) and spectrometric methods (ESIMS). The low potency exhibited by daucovirgolides I-L further supports the observation that strict structural requirements do exist for the Plasmodium transmission blocking activity in the daucovirgolide series. In particular, the endocyclic double bond system seems to be crucial for bioactivity
Plakortin (1) is a remarkably simple 1,2-dioxane derivative, extracted from the marine sponge Plakor...
A new isodaucane sesquiterpenoid, 6,7,10-trihydoxyisodaucane, was isolated from the fruits of Reneil...
Abstract Background Optimal adoption of the malaria transmission-blocking strategy is currently limi...
Repeated chromatographic purifications of aerial parts of the Tunisian plant Daucus virgatus led to ...
Phytochemical investigation of the aerial parts of the Tunisian plant Daucus virgatus led to the iso...
Chemical analysis of the aerial parts obtained from a Tunisian specimen of Daucus carota yielded to ...
Fig. 4. Structures of compound 2 and daucovirgolide G (9).Published as part of Sirignano, Carmina, H...
Fig. 1. Chemical structures of compounds isolated from D. carota.Published as part of Sirignano, Car...
Chemical analysis of the aerial parts obtained from the Northern African endemic plant Daucus virgat...
The aims of the present study were to identify the compounds responsible for the anti-malarial activ...
A 1,7-bis(alkylamino)diazachrysene-based small molecule was previously identified as an inhibitor of...
A 1,7-bis(alkylamino)diazachrysene-based small molecule was previously identified as an inhibitor of...
A new aporphine alkaloid, 7-epi-duguetine (1) together with one known alkaloid, dicentrinone (2), an...
Previously reported pyrrolones, such as TDR32570, exhibited potential as antimalarial agents; howeve...
PhD (Pharmaceutical Chemistry), North-West University, Potchefstroom Campus, 2014Malaria is endemic ...
Plakortin (1) is a remarkably simple 1,2-dioxane derivative, extracted from the marine sponge Plakor...
A new isodaucane sesquiterpenoid, 6,7,10-trihydoxyisodaucane, was isolated from the fruits of Reneil...
Abstract Background Optimal adoption of the malaria transmission-blocking strategy is currently limi...
Repeated chromatographic purifications of aerial parts of the Tunisian plant Daucus virgatus led to ...
Phytochemical investigation of the aerial parts of the Tunisian plant Daucus virgatus led to the iso...
Chemical analysis of the aerial parts obtained from a Tunisian specimen of Daucus carota yielded to ...
Fig. 4. Structures of compound 2 and daucovirgolide G (9).Published as part of Sirignano, Carmina, H...
Fig. 1. Chemical structures of compounds isolated from D. carota.Published as part of Sirignano, Car...
Chemical analysis of the aerial parts obtained from the Northern African endemic plant Daucus virgat...
The aims of the present study were to identify the compounds responsible for the anti-malarial activ...
A 1,7-bis(alkylamino)diazachrysene-based small molecule was previously identified as an inhibitor of...
A 1,7-bis(alkylamino)diazachrysene-based small molecule was previously identified as an inhibitor of...
A new aporphine alkaloid, 7-epi-duguetine (1) together with one known alkaloid, dicentrinone (2), an...
Previously reported pyrrolones, such as TDR32570, exhibited potential as antimalarial agents; howeve...
PhD (Pharmaceutical Chemistry), North-West University, Potchefstroom Campus, 2014Malaria is endemic ...
Plakortin (1) is a remarkably simple 1,2-dioxane derivative, extracted from the marine sponge Plakor...
A new isodaucane sesquiterpenoid, 6,7,10-trihydoxyisodaucane, was isolated from the fruits of Reneil...
Abstract Background Optimal adoption of the malaria transmission-blocking strategy is currently limi...