Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection with a hospital mortality in excess of 40%. Along with insufficient and delayed empirical antimicrobial therapy, inappropriate antimicrobial exposure has been identified to negatively affect patient outcomes. Receipt of prolonged infusion (i.e. extended or continuous infusion) of piperacillin/tazobactam (TZP) improves antimicrobial exposure and is associated with reduced mortality in patients with sepsis. Using therapeutic drug monitoring (TDM) with dosing tailored to the altered pharmacokinetics of the individual patient to avoid under- and overdosing may be a further strategy to improve patient outcomes. This current trial will address the q...
Objectives: We utilized the database of the Defining Antibiotic Levels in Intensive care unit patien...
Objectives:We utilized the database of the Defining Antibiotic Levels in Intensive care unit patient...
Objective: Kinetics of piperacillin (pip), in combination with the beta-lactamase inhibitor tazobact...
Background: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to...
Purpose: Standard dosing and intermittent bolus application (IB) are important risk factors for phar...
To evaluate target attainment of empirically dosed continuous infusion piperacillin/tazobactam (TZP)...
Purpose: There is variability in the pharmacokinetics (PK) of antibiotics (AB) in critically ill pat...
The clinical efficacy of continuous infusion of piperacillin/tazobactam in critically ill patients w...
Therapeutic drug monitoring (TDM) is increasingly relevant for an individualized antibiotic therapy ...
The clinical efficacy of continuous infusion of piperacillin/tazobactam in critically ill patients w...
The clinical efficacy of continuous infusion of piperacillin/tazobactam in critically ill patients w...
The clinical efficacy of continuous infusion of piperacillin/tazobactam in critically ill patients w...
BACKGROUND AND OBJECTIVES: Although dose optimization studies have been performed for piperacillin a...
Objectives: We utilized the database of the Defining Antibiotic Levels in Intensive care unit patien...
BackgroundSeveral studies have indicated that commonly used piperacillin-tazobactam (TZP) and merope...
Objectives: We utilized the database of the Defining Antibiotic Levels in Intensive care unit patien...
Objectives:We utilized the database of the Defining Antibiotic Levels in Intensive care unit patient...
Objective: Kinetics of piperacillin (pip), in combination with the beta-lactamase inhibitor tazobact...
Background: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to...
Purpose: Standard dosing and intermittent bolus application (IB) are important risk factors for phar...
To evaluate target attainment of empirically dosed continuous infusion piperacillin/tazobactam (TZP)...
Purpose: There is variability in the pharmacokinetics (PK) of antibiotics (AB) in critically ill pat...
The clinical efficacy of continuous infusion of piperacillin/tazobactam in critically ill patients w...
Therapeutic drug monitoring (TDM) is increasingly relevant for an individualized antibiotic therapy ...
The clinical efficacy of continuous infusion of piperacillin/tazobactam in critically ill patients w...
The clinical efficacy of continuous infusion of piperacillin/tazobactam in critically ill patients w...
The clinical efficacy of continuous infusion of piperacillin/tazobactam in critically ill patients w...
BACKGROUND AND OBJECTIVES: Although dose optimization studies have been performed for piperacillin a...
Objectives: We utilized the database of the Defining Antibiotic Levels in Intensive care unit patien...
BackgroundSeveral studies have indicated that commonly used piperacillin-tazobactam (TZP) and merope...
Objectives: We utilized the database of the Defining Antibiotic Levels in Intensive care unit patien...
Objectives:We utilized the database of the Defining Antibiotic Levels in Intensive care unit patient...
Objective: Kinetics of piperacillin (pip), in combination with the beta-lactamase inhibitor tazobact...