Control of biofouling has been one of the major challenges in pearl culture. Field experiments were performed to control the biofouling in farmed pearl oyster Pinctada fucata by treating the oysters first with 5% acetic acid at different time interval (2, 5, 10 min) and then kept for evaluation at three depths (1, 3, 5 m). The average total fouling biomass on oysters exposed for 2, 5, 10 min were 7.35, 6.97 and 6.49 g/oyster/month respectively, while control showed 10.56 g/oyster/month on completion of four months. Mortality of oysters were 60, 29, 14% at 10, 5 and 2 min exposure and control had only 7%. There was significant differences in total fouling biomass and mortality between the control and treatments (p<0.001). Results suggest tha...