Natural history, treatment, and long-term follow up of patients with multiple endocrine neoplasia type 2B: an international, multicentre, retrospective study.
- Castinetti, F
- Waguespack, SG
- Machens, A
- Uchino, S
- Hasse-Lazar, K
- Sanso, G
- Else, T
- Dvorakova, S
- Qi, XP
- Elisei, R
- Maia, AL
- Glod, J
- Lourenço, DM
- Valdes, N
- Mathiesen, J
- Wohllk, N
- Bandgar, TR
- Drui, D
- Korbonits, M
- Druce, MR
- Brain, C
- Kurzawinski, T
- Patocs, A
- Bugalho, MJ
- Lacroix, A
- Caron, P
- Fainstein-Day, P
- Borson Chazot, F
- Klein, M
- Links, TP
- Letizia, C
- Fugazzola, L
- Chabre, O
- Canu, L
- Cohen, R
- Tabarin, A
- Spehar Uroic, A
- Maiter, D
- Laboureau, S
- Mian, C
- Peczkowska, M
- Sebag, F
- Brue, T
- Mirebeau-Prunier, D
- Leclerc, L
- Bausch, B
- Berdelou, A
- Sukurai, A
- Vlcek, P
- Krajewska, J
- Barontini, M
- Vaz Ferreira Vargas, C
- Valerio, L
- Ceolin, L
- Akshintala, S
- Hoff, A
- Godballe, C
- Jarzab, B
- Jimenez, C
- Eng, C
- Imai, T
- Schlumberger, M
- Grubbs, E
- Dralle, H
- Neumann, HP
- Baudin, E
DOIAbstract
BACKGROUND: Multiple endocrine neoplasia type 2B is a rare syndrome caused mainly by Met918Thr germline RET mutation, and characterised by medullary thyroid carcinoma, phaeochromocytoma, and extra-endocrine features. Data are scarce on the natural history of multiple endocrine neoplasia type 2B. We aimed to advance understanding of the phenotype and natural history of multiple endocrine neoplasia type 2B, to increase awareness and improve detection. METHODS: This study was a retrospective, multicentre, international study in patients carrying the Met918Thr RET variant with no age restrictions. The study was done with registry data from 48 centres globally. Data from patients followed-up from 1970 to 2016 were retrieved from May 1, 2016, to ...
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