Adaptive type 2 immune responses against the intestinal helminth Heligmosomoides polygyrus (Hp) require the interaction of follicle-associated CXCR5 <sup>+</sup> dendritic cells with naive T cells in the draining mesenteric lymph nodes (mLNs). However, the source of CXCL13 responsible for attracting CXCR5 <sup>+</sup> dendritic cells has remained unclear. Using multiplex imaging combined with deep tissue analysis, we observed new CXCL13 <sup>+</sup> fibroblastic reticular cells surrounding paracortical and cortical B cell follicles in the mLNs of infected mice. CXCL13 <sup>+</sup> fibroblasts expressed markers of marginal reticular cells (MRCs), and their expansion required lymphotoxin (LT)-de...
SummaryWithin secondary lymphoid tissues, stromal reticular cells support lymphocyte function, and t...
The homeostatic chemokine CXCL13 is preferentially produced in B-follicles and is crucial in the lym...
The transfer of lymphocytes into severe combined immunodeficiency (SCID) mice induces a series of hi...
Adaptive type 2 immune responses against the intestinal helminth Heligmosomoides polygyrus (Hp) requ...
Summary: Adaptive type 2 immune responses against the intestinal helminth Heligmosomoides polygyrus ...
Adaptive type 2 immune responses against the intestinal helminth Heligmosomoides polygyrus (Hp) requ...
Secondary lymphoid tissues provide specialized niches for the initiation of adaptive immune response...
SummarySecondary lymphoid tissues provide specialized niches for the initiation of adaptive immune r...
Lymphatic growth (lymphangiogenesis) within lymph nodes functions to promote dendritic cell entry an...
SummaryThe stromal scaffold of the lymph node (LN) paracortex is built by fibroblastic reticular cel...
Lymphoid follicles are B-cell-rich compartments of lymphoid organs that function as sites of B-cell ...
SummaryThe differentiation of follicular dendritic cells (FDC) is essential to the remarkable microa...
Ectopic lymphoid follicles are a key feature of chronic inflammatory autoimmune and infectious disea...
Ectopic or tertiary lymphoid tissues (TLTs) are often induced at sites of chronic inflammation. They...
Through the formation of concentration gradients, morphogens drive graded responses to extracellular...
SummaryWithin secondary lymphoid tissues, stromal reticular cells support lymphocyte function, and t...
The homeostatic chemokine CXCL13 is preferentially produced in B-follicles and is crucial in the lym...
The transfer of lymphocytes into severe combined immunodeficiency (SCID) mice induces a series of hi...
Adaptive type 2 immune responses against the intestinal helminth Heligmosomoides polygyrus (Hp) requ...
Summary: Adaptive type 2 immune responses against the intestinal helminth Heligmosomoides polygyrus ...
Adaptive type 2 immune responses against the intestinal helminth Heligmosomoides polygyrus (Hp) requ...
Secondary lymphoid tissues provide specialized niches for the initiation of adaptive immune response...
SummarySecondary lymphoid tissues provide specialized niches for the initiation of adaptive immune r...
Lymphatic growth (lymphangiogenesis) within lymph nodes functions to promote dendritic cell entry an...
SummaryThe stromal scaffold of the lymph node (LN) paracortex is built by fibroblastic reticular cel...
Lymphoid follicles are B-cell-rich compartments of lymphoid organs that function as sites of B-cell ...
SummaryThe differentiation of follicular dendritic cells (FDC) is essential to the remarkable microa...
Ectopic lymphoid follicles are a key feature of chronic inflammatory autoimmune and infectious disea...
Ectopic or tertiary lymphoid tissues (TLTs) are often induced at sites of chronic inflammation. They...
Through the formation of concentration gradients, morphogens drive graded responses to extracellular...
SummaryWithin secondary lymphoid tissues, stromal reticular cells support lymphocyte function, and t...
The homeostatic chemokine CXCL13 is preferentially produced in B-follicles and is crucial in the lym...
The transfer of lymphocytes into severe combined immunodeficiency (SCID) mice induces a series of hi...