Changes in the concentration of neurochemicals, including neurotransmitters, neuromodulators and metabolites, reflect the complex interactions within local and global neural networks. The assessment of such changes promises thus insights into neural communications; in particular if several neurochemicals can be studied at the same time. Here we report findings from chemical analysis of six polar neurochemicals, including acetylcholine (ACh), choline, glutamine, glutamate, lactate and pyruvate, by means of hydrophilic interaction chromatography (HILIC) coupled to tandem mass spectrometry (MS/MS). Extracellular fluid was withdrawn at 40 nl/min by nano push-pull perfusion (NFP3) and collected in vials for sequence analyses. We have successfull...
Neurotransmitters are signaling molecules, playing key roles in neuronal communications in the brain...
Neurotransmitter concentration in vivo reflects various behavioral and pharmacological events. There...
Improving our understanding of the central nervous system necessitates developing techniques capable...
A diverse array of neurotransmitters and neuromodulators control and affect brain function. A profou...
A diverse array of neurotransmitters and neuromodulators control and affect brain function. A profou...
Proper brain function is tightly controlled by neurochemically active compounds (NACs). These NACs c...
In vivo measurement of multiple functionally related neurochemicals and metabolites (NMs) is highly ...
The extracellular fluid (ECF) is the complex, dynamic environment embedding the neurons where neuroc...
The extracellular compartment of the brain is a complex, dynamic microenvironment containing nutrien...
Acetylcholine (ACh) can enhance the amplitude of synaptic potentials and thereby exert an influence ...
Acetylcholine (ACh) is believed to play a major role in attentional processing in cortex, thereby co...
Acetylcholine (Ach) is believed to play a major role in attentional processing in cortex, thereby co...
The analysis of neurochemicals from the brain represents a challenge for current analytical techniqu...
Neurotransmitters are endogenous metabolites that allow the signal transmission across neuronal syna...
International audienceAcetylcholine is the neurotransmitter of the parasympathetic nervous system, s...
Neurotransmitters are signaling molecules, playing key roles in neuronal communications in the brain...
Neurotransmitter concentration in vivo reflects various behavioral and pharmacological events. There...
Improving our understanding of the central nervous system necessitates developing techniques capable...
A diverse array of neurotransmitters and neuromodulators control and affect brain function. A profou...
A diverse array of neurotransmitters and neuromodulators control and affect brain function. A profou...
Proper brain function is tightly controlled by neurochemically active compounds (NACs). These NACs c...
In vivo measurement of multiple functionally related neurochemicals and metabolites (NMs) is highly ...
The extracellular fluid (ECF) is the complex, dynamic environment embedding the neurons where neuroc...
The extracellular compartment of the brain is a complex, dynamic microenvironment containing nutrien...
Acetylcholine (ACh) can enhance the amplitude of synaptic potentials and thereby exert an influence ...
Acetylcholine (ACh) is believed to play a major role in attentional processing in cortex, thereby co...
Acetylcholine (Ach) is believed to play a major role in attentional processing in cortex, thereby co...
The analysis of neurochemicals from the brain represents a challenge for current analytical techniqu...
Neurotransmitters are endogenous metabolites that allow the signal transmission across neuronal syna...
International audienceAcetylcholine is the neurotransmitter of the parasympathetic nervous system, s...
Neurotransmitters are signaling molecules, playing key roles in neuronal communications in the brain...
Neurotransmitter concentration in vivo reflects various behavioral and pharmacological events. There...
Improving our understanding of the central nervous system necessitates developing techniques capable...