Enzymatic cyclization of the linear polyketide chain to form a macrolactone is a key step in the biosynthesis of type I polyketide natural products. Structural biology and inhibitor design were used to gain insight into the mechanism and specificity of this enzymatic process
Resorcylic acid lactones and dihydroxyphenylacetic acid lactones represent important pharmacophores ...
Natural products continue to inspire scientists on the search for biological active structures. Rece...
Polyketides are a diverse group of natural products that form the basis of many important drugs. The...
Aldol reactions belong to the most important methods for carbon–carbon bond formation and are also i...
The structural scaffolds of many complex natural products are produced by multifunctional type I pol...
Compounds of polyketide origin possess a wealth of pharmacological effects, including antibacterial,...
Polyketide synthases catalyze the assembly of complex natural products from simple precursors such a...
Polyketide synthases are enormous modular enzymes that synthesize large acyl chains known as polyket...
Polyketide natural products represent a diverse set of chemical entities that are prized by organic ...
Modular polyketide synthases and nonribosomal peptide synthetases are giant multienzymes that cataly...
<p>The key steps in type II polyketide biosynthesis—priming of the minimal polyketide synthase, exte...
Complex polyketides comprise a large number of natural products that have broad application in medic...
AbstractNumerous bioactive natural products are synthesised by modular polyketide synthases. These c...
International audiencePolyketides are a fascinating class of natural products with highly diverse, o...
AbstractMulti-enzyme systems such as those involved in the biosynthesis of polyketides, typically ca...
Resorcylic acid lactones and dihydroxyphenylacetic acid lactones represent important pharmacophores ...
Natural products continue to inspire scientists on the search for biological active structures. Rece...
Polyketides are a diverse group of natural products that form the basis of many important drugs. The...
Aldol reactions belong to the most important methods for carbon–carbon bond formation and are also i...
The structural scaffolds of many complex natural products are produced by multifunctional type I pol...
Compounds of polyketide origin possess a wealth of pharmacological effects, including antibacterial,...
Polyketide synthases catalyze the assembly of complex natural products from simple precursors such a...
Polyketide synthases are enormous modular enzymes that synthesize large acyl chains known as polyket...
Polyketide natural products represent a diverse set of chemical entities that are prized by organic ...
Modular polyketide synthases and nonribosomal peptide synthetases are giant multienzymes that cataly...
<p>The key steps in type II polyketide biosynthesis—priming of the minimal polyketide synthase, exte...
Complex polyketides comprise a large number of natural products that have broad application in medic...
AbstractNumerous bioactive natural products are synthesised by modular polyketide synthases. These c...
International audiencePolyketides are a fascinating class of natural products with highly diverse, o...
AbstractMulti-enzyme systems such as those involved in the biosynthesis of polyketides, typically ca...
Resorcylic acid lactones and dihydroxyphenylacetic acid lactones represent important pharmacophores ...
Natural products continue to inspire scientists on the search for biological active structures. Rece...
Polyketides are a diverse group of natural products that form the basis of many important drugs. The...
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