Several neurological disorders are linked to tandem nucleotide repeat expansion in the mutated gene. Jain and Vale (2017. Nature. https://doi.org/10.1038/nature22386) show that, above a pathological threshold repeat number, base pairing interactions drive phase separation of RNA into membrane-less gels, suggesting that RNA can scaffold the assembly of phase-separated compartments that sequester proteins/RNAs causing toxicity
Summary: Amyloid bodies (A-bodies) are inducible membrane-less nuclear compartments composed of hete...
Although it is known that RNA undergoes liquid–liquid phase separation, the interplay between the mo...
RNA viruses that replicate in the cell cytoplasm typically concentrate their replication machinery w...
Expansions of short nucleotide repeats produce several neurological and neuromuscular disorders incl...
Changes in the abundance of protein and RNA molecules can impair the formation of complexes in the c...
Subcellular compartmentalization contributes to the organization of a plethora of molecular events o...
Prion-like RNA binding proteins (RBPs) such as TDP43 and FUS are largely soluble in the nucleus but ...
The number of neurodegenerative diseases resulting from repeat expansion has increased extraordinari...
Prion-like RNA binding proteins (RBPs) such as TDP43 and FUS are largely soluble in the nucleus but ...
Human Satellite II, a tandemly repeated stretch of DNA found near the centromeres of most human chro...
AbstractRNA-mediated mechanisms of disease pathogenesis in neurological disorders have been recogniz...
Summary: Recent evidence indicates that specific RNAs promote the formation of ribonucleoprotein con...
One of the key mechanisms employed by cells to control their spatiotemporal organization is the form...
Recent work has revealed the importance of liquid-liquid phase separation (LLPS) as a mechanism to o...
The expansion of tandem repeat sequences beyond a pathogenic threshold is responsible for a series o...
Summary: Amyloid bodies (A-bodies) are inducible membrane-less nuclear compartments composed of hete...
Although it is known that RNA undergoes liquid–liquid phase separation, the interplay between the mo...
RNA viruses that replicate in the cell cytoplasm typically concentrate their replication machinery w...
Expansions of short nucleotide repeats produce several neurological and neuromuscular disorders incl...
Changes in the abundance of protein and RNA molecules can impair the formation of complexes in the c...
Subcellular compartmentalization contributes to the organization of a plethora of molecular events o...
Prion-like RNA binding proteins (RBPs) such as TDP43 and FUS are largely soluble in the nucleus but ...
The number of neurodegenerative diseases resulting from repeat expansion has increased extraordinari...
Prion-like RNA binding proteins (RBPs) such as TDP43 and FUS are largely soluble in the nucleus but ...
Human Satellite II, a tandemly repeated stretch of DNA found near the centromeres of most human chro...
AbstractRNA-mediated mechanisms of disease pathogenesis in neurological disorders have been recogniz...
Summary: Recent evidence indicates that specific RNAs promote the formation of ribonucleoprotein con...
One of the key mechanisms employed by cells to control their spatiotemporal organization is the form...
Recent work has revealed the importance of liquid-liquid phase separation (LLPS) as a mechanism to o...
The expansion of tandem repeat sequences beyond a pathogenic threshold is responsible for a series o...
Summary: Amyloid bodies (A-bodies) are inducible membrane-less nuclear compartments composed of hete...
Although it is known that RNA undergoes liquid–liquid phase separation, the interplay between the mo...
RNA viruses that replicate in the cell cytoplasm typically concentrate their replication machinery w...
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