Investigating the Role of Choroid Plexus in CSF Pulsation by Combining In-Vivo & Post-Mortem MRI

Cerebrospinal fluid (CSF) shows pulsating dynamics, due to the transmission of the cardiac pulse pressure wave to the ventricular system. The exact description of this transmission is still debated in the scientific community. Several studies have shown choroid plexus (CP) to play an important role to establish CSF dynamics. In the presented study, we evaluated volumes of CP by post-mortem bSSFP MRI and compared them to in-vivo CSF flow measurements. Our results showed a very small volumetric deformation of CP to be necessary to induce in-vivo CSF strokes in the cerebral aqueduct