Psoromic acid derivatives: A new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay.

Snapshots of spliceosome assembly: A high-throughput in vitro splicing assay has been developed for screening a compound library. The discovered family of pre-mRNA splicing inhibitors comprises lichen secondary metabolites that allow the enrichment of the spliceosomal complexes formed after the spliceosome activation step. Here we identify the structural features important for the compounds' inhibitory activity