Spliceosomes are multi-megadalton RNA-protein molecular machines that carry out pre-mRNA splicing, that is, the removal of non-coding intervening sequences (introns) from eukaryotic pre-mRNAs and the ligation of neighboring coding regions (exons) to produce mature mRNA for protein biosynthesis on the ribosome. They are the prototypes of dynamic molecular machines, assembling de novo for each splicing event by the stepwise recruitment of subunits on a substrate
ConspectusIntron removal from premature-mRNA (pre-mRNA splicing) is an essential part of gene expres...
Most human genes are composed of coding sequences (exons) that are interrupted by non-coding sequenc...
Intron removal from premature-mRNA (pre-mRNA splicing) is an essential part of gene expression and r...
Spliceosomes are multi-megadalton RNA-protein molecular machines that carry out pre-mRNA splicing, t...
Spliceosomes are multi-megadalton RNA-protein molecular machines that carry out pre-mRNA splicing, t...
Spliceosomes are multi-megadalton RNA-protein molecular machines that carry out pre-mRNA splicing, t...
Numerous mechanisms exploit or modulate the conformational/compositional dynamics of spliceosomes to...
Tools to understand how the spliceosome functions in vivo have lagged behind advances in the st...
Most eukaryotic pre-mRNAs contain non-coding sequences (introns) that must be removed in order to ac...
The spliceosome (SPL) is a majestic macromolecular machinery composed of five small nuclear RNAs and...
Pre-mRNA splicing is an essential step in eukaryotic gene expression. Splicing is catalyzed by the ...
Ribonucleoproteins (RNPs) mediate key cellular functions such as gene expression and its regulation....
Eukaryotic genes contain non-coding introns, removal of which during gene expression is a pre-requis...
The spliceosome is a large RNA‐protein complex that catalyses the removal of introns from nuclear pr...
The spliceosome is a eukaryotic molecular machine composed of uridine-rich small nuclear RNAs (U snR...
ConspectusIntron removal from premature-mRNA (pre-mRNA splicing) is an essential part of gene expres...
Most human genes are composed of coding sequences (exons) that are interrupted by non-coding sequenc...
Intron removal from premature-mRNA (pre-mRNA splicing) is an essential part of gene expression and r...
Spliceosomes are multi-megadalton RNA-protein molecular machines that carry out pre-mRNA splicing, t...
Spliceosomes are multi-megadalton RNA-protein molecular machines that carry out pre-mRNA splicing, t...
Spliceosomes are multi-megadalton RNA-protein molecular machines that carry out pre-mRNA splicing, t...
Numerous mechanisms exploit or modulate the conformational/compositional dynamics of spliceosomes to...
Tools to understand how the spliceosome functions in vivo have lagged behind advances in the st...
Most eukaryotic pre-mRNAs contain non-coding sequences (introns) that must be removed in order to ac...
The spliceosome (SPL) is a majestic macromolecular machinery composed of five small nuclear RNAs and...
Pre-mRNA splicing is an essential step in eukaryotic gene expression. Splicing is catalyzed by the ...
Ribonucleoproteins (RNPs) mediate key cellular functions such as gene expression and its regulation....
Eukaryotic genes contain non-coding introns, removal of which during gene expression is a pre-requis...
The spliceosome is a large RNA‐protein complex that catalyses the removal of introns from nuclear pr...
The spliceosome is a eukaryotic molecular machine composed of uridine-rich small nuclear RNAs (U snR...
ConspectusIntron removal from premature-mRNA (pre-mRNA splicing) is an essential part of gene expres...
Most human genes are composed of coding sequences (exons) that are interrupted by non-coding sequenc...
Intron removal from premature-mRNA (pre-mRNA splicing) is an essential part of gene expression and r...
DOI
Add to ORKG