Licht ins Dunkel bringen

The recently introduced sub-diffraction light microscopy techniques (STORM, STED, PALM etc.) are all based on the fluorescence phenomenon. However, the common drawback of fluorescence-based methods is the lack of structural information about the unlabeled environment. Correlating super-resolution images with structural information obtained by transmitted light or electron microscopy leads to a better interpretation of super-resolution data and provides a more complete view on any given problem